Document 0123
 DOCN  M9650123
 TI    Relationship between infectious cell-associated human immunodeficiency
       virus type 1 load, T lymphocyte subsets, and stage of infection in
       homosexual men.
 DT    9605
 AU    Margolick JB; Farzadegan H; Hoover DR; Saah AJ; Department of Molecular
       Microbiology and Immunology, Johns; Hopkins University School of Hygiene
       and Public Health, Baltimore; 21205, USA.
 SO    J Infect Dis. 1996 Feb;173(2):468-71. Unique Identifier : AIDSLINE
       MED/96162111
 AB    The relationship between cell-associated infectious human
       immunodeficiency virus type 1 (HIV) load (infectious units/10(6)
       peripheral blood mononuclear cells [IUPM]) and phenotypes of CD4+ and
       CD8+ lymphocytes was studied. IUPM were measured in 242 HIV-infected
       homosexual men by quantitative microculture and T cell subsets by
       two-color flow cytometry. In multivariate analysis, IUPM correlated
       negatively with CD4+ lymphocyte level and with a diagnosis of AIDS and
       positively with the proportion of CD8+ lymphocytes expressing the
       activation marker CD38. After adjusting for level of CD4+ lymphocytes,
       men with AIDS had significantly lower IUPM than those without AIDS. The
       correlation between IUPM and CD4+ lymphocyte level was largely explained
       by correlation with level of CD4+ lymphocytes with resting phenotypes
       (HLA-DR-, CD38-) rather than with those expressing HLA-DR and CD38.
       Thus, subsets of CD4+ lymphocytes may vary in cell-associated infectious
       HIV content at different stages of HIV infection.
 DE    Acquired Immunodeficiency Syndrome/*IMMUNOLOGY/PHYSIOPATHOLOGY/
       VIROLOGY  Antigens, CD/IMMUNOLOGY  Cross-Sectional Studies  CD4
       Lymphocyte Count  CD4-Positive T-Lymphocytes/IMMUNOLOGY  CD8-Positive
       T-Lymphocytes/IMMUNOLOGY  Flow Cytometry  *Homosexuality, Male  Human
       HIV-1/*PHYSIOLOGY  HLA-DR Antigens/IMMUNOLOGY  Immunophenotyping
       Leukocytes, Mononuclear/VIROLOGY  Male  Support, U.S. Gov't, P.H.S.
       T-Lymphocyte Subsets/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).