Document 0124
 DOCN  M9650124
 TI    Soluble tumor necrosis factor-alpha receptor type II (sTNF alpha RII)
       correlates with human immunodeficiency virus (HIV) RNA copy number in
       HIV-infected patients.
 DT    9605
 AU    Bilello JA; Stellrecht K; Drusano GL; Stein DS; Department of Medicine,
       Albany Medical College, New York 12208,; USA.
 SO    J Infect Dis. 1996 Feb;173(2):464-7. Unique Identifier : AIDSLINE
       MED/96162110
 AB    Soluble TNF receptor type II (sTNF alpha RII) levels in serum, CD4
       lymphocyte counts, and human immunodeficiency virus (HIV) burdens have
       each been correlated with HIV disease progression. The level of sTNF
       alpha RII and HIV RNA was measured in serum and the CD4 lymphocyte count
       of 25 HIV-infected patients was determined. sTNF alpha RII ranged
       between 3.019 and 12.57 ng/mL (mean +/- SD, 6.705 +/- 2.5). HIV-1 RNA
       varied from 960 to 281,160 copies/mL (71,988 +/- 75,684). CD4 cell
       number was between 4 and 540/microL (181.3 +/- 152.2). Univariate
       analysis revealed a moderate inverse correlation of sTNF alpha RII with
       CD4 cell number (r = -.41, P < .05) and a strong positive correlation
       between sTNF alpha RII and log RNA copy number (r = .62, P < .001). On
       multivariate analysis, sTNF alpha RII strongly correlated with RNA copy
       number (P < .01) but not CD4 lymphocyte count. sTNF alpha RII
       measurements appear to be predictive of clinical outcomes because they
       are a surrogate indicator of the patients' immunologic response to a
       virus load.
 DE    Cross-Sectional Studies  CD4 Lymphocyte Count  CD4-Positive
       T-Lymphocytes/IMMUNOLOGY  Enzyme-Linked Immunosorbent Assay  Human  HIV
       Infections/*BLOOD/PHYSIOPATHOLOGY/VIROLOGY  HIV
       Seropositivity/BLOOD/PHYSIOPATHOLOGY/VIROLOGY  HIV-1/*GENETICS
       Multivariate Analysis  Polymerase Chain Reaction  Receptors, Tumor
       Necrosis Factor/*ANALYSIS  RNA, Viral/*ANALYSIS  Solubility  Support,
       Non-U.S. Gov't  Viremia/IMMUNOLOGY/PHYSIOPATHOLOGY/*VIROLOGY  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).