Document 0126
 DOCN  M9650126
 TI    Lamivudine or stavudine in two- and three-drug combinations against
       human immunodeficiency virus type 1 replication in vitro.
 DT    9605
 AU    Merrill DP; Moonis M; Chou TC; Hirsch MS; Infectious Disease Unit,
       Massachusetts General Hospital, Harvard; Medical School, Boston 02114,
       USA.
 SO    J Infect Dis. 1996 Feb;173(2):355-64. Unique Identifier : AIDSLINE
       MED/96162093
 AB    Two- and three-drug combinations of lamivudine or stavudine with other
       antiretroviral drugs were evaluated for activity against human
       immunodeficiency virus type 1 (HIV-1) activity in peripheral blood
       mononuclear cells. Other agents included zidovudine, didanosine,
       nevirapine, and saquinavir. Paired zidovudine-sensitive and -resistant
       clinical HIV-1 isolates were used. Additive or synergistic interactions
       were observed against the zidovudine-sensitive isolate with the
       following combinations: lamivudine-zidovudine, lamivudine-stavudine,
       lamivudine-saquinavir, lamivudine-nevirapine, stavudine-zidovudine,
       stavudine-didanosine, stavudine-saquinavir, stavudine-nevirapine,
       lamivudine-zidovudine-saquinavir, lamivudine-zidovudine-stavudine,
       stavudine-zidovudine-nevirapine, lamivudine-zidovudine-nevirapine, and
       stavudine-zidovudine-saquinavir. Against the zidovudine-resistant
       isolate, additive or synergistic interactions were seen with most two-
       and three-drug combinations, but the combination of stavudine-zidovudine
       was antagonistic. The clinical implications of these in vitro
       observations should be explored.
 DE    Antiviral Agents/*PHARMACOLOGY  Comparative Study  Drug Combinations
       Drug Synergism  Human  HIV Seropositivity/VIROLOGY  HIV-1/*DRUG
       EFFECTS/ISOLATION & PURIF/PHYSIOLOGY  Reverse Transcriptase
       Inhibitors/*PHARMACOLOGY  RNA-Directed DNA Polymerase/DRUG EFFECTS
       Stavudine/*PHARMACOLOGY  Support, Non-U.S. Gov't  Support, U.S. Gov't,
       P.H.S.  Virus Replication/*DRUG EFFECTS  Zalcitabine/*ANALOGS &
       DERIVATIVES/PHARMACOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).