Document 0140
 DOCN  M9650140
 TI    CD30 expression does not discriminate between human Th1- and Th2-type T
       cells.
 DT    9605
 AU    Hamann D; Hilkens CM; Grogan JL; Lens SM; Kapsenberg ML; Yazdanbakhsh M;
       van Lier RA; Central Laboratory of the Netherlands Red Cross Blood
       Transfusion; Service, University of Amsterdam, The Netherlands.
 SO    J Immunol. 1996 Feb 15;156(4):1387-91. Unique Identifier : AIDSLINE
       MED/96164564
 AB    CD30 is a member of the TNF receptor superfamily that is commonly used
       as a marker for Hodgkin and Reed-Sternberg cells in Hodgkin's disease.
       More recently, it has been proposed that CD30 is preferentially
       up-regulated on Th2-type human T cells. We analyzed regulation of CD30
       expression on both peripheral blood T cells and T cell clones. In
       short-term culture, CD30 expression could be induced on T cells by Ags
       that elicit Th2-type responses (Schistosoma haematobium, adult worm Ag,
       and Toxocaria canis, excretory/secretory Ag) and Th0-type responses
       (tetanus toxoid), as well as Th1-type responses (tuberculin purified
       protein derivative). Moreover, simultaneous measurement of membrane
       phenotype and cytokine production showed that CD30-expressing cells can
       produce IFN-gamma. Finally, within panels of randomly generated as well
       as Ag-specific T cell clones, CD30 expression was found on Th0-, Th2-,
       and Th1-type clones. We conclude that induction of CD30 on activated T
       cells is not related to differentiation in Th0-, Th1-, or Th2-type
       cells.
 DE    Antigens, CD30/*METABOLISM  Cell Differentiation  Human  Interferon Type
       II/BIOSYNTHESIS  Lymphocyte Transformation  Support, Non-U.S. Gov't  Th1
       Cells/*IMMUNOLOGY  Th2 Cells/*IMMUNOLOGY  Up-Regulation (Physiology)
       JOURNAL ARTICLE

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