Document 0142
 DOCN  M9650142
 TI    [Bilateral acute retinal necrosis in a patient with acquired
       immunodeficiency syndrome]
 DT    9605
 AU    Menerath JM; Gerard M; Laurichesse H; Goldschmidt P; Peigue-Lafeuille H;
       Rozenberg F; Beytout J; Service d'Ophtalmologie, Hopital Gabriel
       Montpied, CHU, BP 69,; Clermont-Ferrand.
 SO    J Fr Ophtalmol. 1995;18(10):625-33. Unique Identifier : AIDSLINE
       MED/96146818
 AB    A case of bilateral progressive outer retinal necrosis occurred after
       herpes zoster ophthalmicus in a patient with acquired immunodeficiency
       syndrome. This case does not correspond to the classical picture of
       progressive outer retinal necrosis. The disease led to blindness despite
       intravenous therapy with acyclovir and foscarnet. PCR could not identify
       any virus in the aqueous humour, but VZV is evidenced in cerebrospinal
       fluid. Acute retinal necrosis is now clearly defined by the American
       Uveitis Society, which should allow to determine its incidence and risk
       factors. Herpes zoster usually precedes the acute outer retinal
       necrosis. The infectious theory (VZV, HSV, CMV) widely prevails over the
       immune theory. We prefer the virus genome identification in the aqueous
       humor or in the vitreous by PCR to confirm diagnosis rather than the
       specific antibody titration. Therapy consists in acyclovir, foscarnet
       and ganciclovir. But whatever the treatment, the visual prognosis is
       poor.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS/THERAPY  Antiviral
       Agents/THERAPEUTIC USE  Case Report  English Abstract  Herpes Zoster
       Ophthalmicus/ETIOLOGY/PHYSIOPATHOLOGY/THERAPY  Human  Male  Middle Age
       Retinal Necrosis Syndrome, Acute/*ETIOLOGY/PHYSIOPATHOLOGY/  THERAPY
       JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).