Document 0144
 DOCN  M9650144
 TI    [Prognosis of retinal detachment in cytomegalovirus retinitis]
 DT    9605
 AU    Cochereau I; Korobelnik JF; Petit E; Matheron S; Longuet P; Hoang-Xuan
       T; Service d'Ophtalmologie, Hopital Bichat-Claude-Bernard, Paris,;
       France.
 SO    J Fr Ophtalmol. 1995;18(10):603-7. Unique Identifier : AIDSLINE
       MED/96146813
 AB    PURPOSE: To evaluate the incidence and the prognosis of retinal
       detachment in CMV retinitis in AIDS. To test intravitreal injections of
       ganciclovir into the vitreal cavity filled with silicone. METHODS: Among
       136 eyes with CMV retinitis, 15 (11%) had retinal detachment. Ten eyes
       underwent intraocular surgery with injection of silicone oil, one
       extraocular surgery and four eyes were not operated. Later, four eyes
       filled with silicone received intravitreal injections of ganciclovir.
       RESULTS: At 2 months, the retina was flat in all the operated eyes, with
       a visual acuity improved or stabilized in 8 cases (73%). Conversely,
       visual acuity was lost in all the unoperated eyes. The 14 intravitreal
       injections of ganciclovir performed in four eyes (which received 2, 3, 3
       or 6 injections, respectively) were well tolerated. CONCLUSION: Surgery
       of retinal detachment in CMV retinitis usually allows the conservation
       of ambulatory visual acuity. Its indications must be discussed together
       with the patient, the ophthalmologist and the physician. Intravitreal
       injections of ganciclovir in vitreal cavity filled with silicone oil are
       possible.
 DE    Adult  Antiviral Agents/THERAPEUTIC USE  AIDS-Related Opportunistic
       Infections/*COMPLICATIONS/SURGERY/  THERAPY  Cytomegalovirus
       Retinitis/*COMPLICATIONS/SURGERY/THERAPY  English Abstract  Female
       Ganciclovir/THERAPEUTIC USE  Human  Male  Middle Age  Prognosis  Retinal
       Detachment/*ETIOLOGY/SURGERY/THERAPY  Risk Factors  Silicone
       Oils/ADMINISTRATION & DOSAGE  Vitrectomy  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).