Document 0151
 DOCN  M9650151
 TI    Lymphocyte subset counts in skin puncture and venous blood compared.
 DT    9605
 AU    Cracknell SE; Hinchliffe RF; Lilleyman JS; University of Sheffield
       Department of Paediatrics, Children's; Hospital, Western Bank.
 SO    J Clin Pathol. 1995 Dec;48(12):1137-8. Unique Identifier : AIDSLINE
       MED/96165060
 AB    To determine whether skin puncture blood can be used reliably for CD4
       lymphocyte counts, the numbers of the major subsets of lymphocytes were
       assessed in paired venous and skin puncture blood samples from 22
       children and 10 adults. Paired values were highly correlated, with skin
       puncture values being about 7% higher than venous values for each cell
       type. Differences were of borderline statistical significance for total
       lymphocytes and for each subset except CD3+ CD8+ T lymphocytes.
       Nevertheless, the magnitude of the differences was small and unlikely to
       be of clinical importance, and it seems that skin puncture samples may
       be preferable for CD4 counts in children or adults with difficult venous
       access.
 DE    Acute Disease  Adolescence  Adult  Blood Specimen Collection/*METHODS
       Child  Child, Preschool  Comparative Study  CD4 Lymphocyte Count  Human
       Infant  Leukemia/IMMUNOLOGY  Lymphocyte Count  *Lymphocyte Subsets
       Phlebotomy  *Punctures  Skin/*BLOOD SUPPLY  CLINICAL TRIAL  CONTROLLED
       CLINICAL TRIAL  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).