Document 0171
 DOCN  M9650171
 TI    Kaposi's sarcoma in childhood: an analysis of 100 cases from Uganda and
       relationship to HIV infection.
 DT    9605
 AU    Ziegler JL; Katongole-Mbidde E; Uganda Cancer Institute, Kampala,
       Uganda.
 SO    Int J Cancer. 1996 Jan 17;65(2):200-3. Unique Identifier : AIDSLINE
       MED/96152770
 AB    We report 100 cases of Kaposi's sarcoma (KS) in children under 15 years
       of age treated at the Uganda Cancer Institute in the 6-year period
       1989-1994. The incidence of childhood KS has risen more than 40-fold in
       the era of AIDS, and 78% of 63 cases tested were seropositive for HIV-1.
       There were 63 boys and 37 girls. The median age was 4 years and the
       median age of onset was 33 months. Tumour distribution was
       lymphadenopathic and muco-cutaneous, with 2 major patterns: pattern I,
       oro-facial dominant (79%); and pattern II, inguinal-genital dominant
       (13%). A newly described herpes-like virus is implicated as the cause of
       KS (KSHV), and DNA sequences of this virus were present in all of 8
       childhood cases tested. If KSHV is a direct cause of KS, this tumour
       distribution in children suggests mucosal routes of virus entry,
       possibly during birth or breast feeding. The dramatic increase of
       childhood KS implies that the prevalence of causative factors is rising
       in Uganda.
 DE    Age Factors  Child, Preschool  Female  Human  HIV
       Infections/*COMPLICATIONS  Infant  Infant, Newborn  Male  Prevalence
       Sarcoma, Kaposi's/EPIDEMIOLOGY/*ETIOLOGY/PHYSIOPATHOLOGY  Sex Factors
       Support, Non-U.S. Gov't  Uganda/EPIDEMIOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).