Document 0172
 DOCN  M9650172
 TI    Over-expression of hepatocyte growth factor in human Kaposi's sarcoma.
 DT    9605
 AU    Maier JA; Mariotti M; Albini A; Comi P; Prat M; Comogilio PM; Soria MR;
       Department of Biological and Technological Research-Dibit, San; Raffaele
       Institute, Milan, Italy.
 SO    Int J Cancer. 1996 Jan 17;65(2):168-72. Unique Identifier : AIDSLINE
       MED/96152765
 AB    Kaposi's sarcoma is a highly vascularized multifocal tumor which
       frequently appears as a complication of HIV infection. It has been
       suggested that a disorder in the cytokine network may contribute to the
       development of the disease. We examined the expression of several
       cytokines in human sporadic Kaposi's-sarcoma specimens, as well as in
       spindle cells cultured from human lesions, and consistently found high
       levels of expression of hepatocyte growth factor (HGF). In addition,
       human lesion-derived spindle cells synthesize and secrete biologically
       active hepatocyte growth factor and express the hepatocyte-growth-factor
       receptor (c-MET). Moreover, elevated levels of transforming growth
       factor beta 1 (TGF beta 1) mRNA were found in lesions of human sporadic
       Kaposi's sarcoma and in lesion-derived spindle cells which also
       over-express urokinase. Since HGF, TGF beta 1 and urokinase are all
       involved in capillary-vessel organization, dysregulation of these
       interacting agents may play a role in the initiation and/or progression
       of Kaposi's sarcoma, stimulating the growth of spindle cells and
       recruiting endothelial cells into the lesion.
 DE    Base Sequence  Fibroblast Growth Factor, Basic/BIOSYNTHESIS  Hepatocyte
       Growth Factor/*BIOSYNTHESIS  Human  Male  Molecular Sequence Data
       Polymerase Chain Reaction  Receptor Protein-Tyrosine Kinase/BIOSYNTHESIS
       RNA, Messenger/*BIOSYNTHESIS  Sarcoma, Kaposi's/*METABOLISM/PATHOLOGY
       Support, Non-U.S. Gov't  Transforming Growth Factor beta/*BIOSYNTHESIS
       Tumor Cells, Cultured  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).