Document 0175
 DOCN  M9650175
 TI    The 5' coding sequence of IL-2 receptor alpha chain mRNA mediates mRNA
       stabilization by HTLV-1 Rex.
 DT    9605
 AU    Kanamori H; Kodama T; Yazaki Y; Third Department of Internal Medicine,
       University of Tokyo,; Japan.
 SO    Immunology. 1995 Dec;86(4):551-5. Unique Identifier : AIDSLINE
       MED/96165031
 AB    The interleukin-2 receptor alpha chain (IL-2R alpha) is a T-cell growth
       factor receptor and is known to be induced in helper T cells by
       infection with human T-cell leukaemia virus type-1 (HTLV-1). The Rex
       protein of HTLV-1 has been shown to stabilize IL-2R alpha mRNA. Although
       the 3' untranslated region of many RNA has been regarded as a key
       element for stabilization, we found that the first 300 bases of the
       IL-2R alpha protein coding sequence were necessary for stabilization of
       the mRNA. As the first 201 bases were not sufficient for this effect, we
       conclude that the bases at position 201-300 downstream of the AUG start
       are important for stabilization.
 DE    Cell Culture  Chloramphenicol Acetyltransferase/GENETICS  Gene Products,
       rex/*GENETICS  Human  HTLV-I/*GENETICS  Plasmids  Receptors,
       Interleukin-2/*GENETICS  RNA, Messenger/CHEMISTRY/*GENETICS  Support,
       Non-U.S. Gov't  Transfection  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).