Document 0182
 DOCN  M9650182
 TI    Response to influenza immunisation in asymptomatic HIV infected men.
 DT    9605
 AU    Huengsberg M; Chakraverty MP; Cooper G; Shahmanesh M; Department of
       Genitourinary Medicine, General Hospital,; Birmingham, UK.
 SO    Genitourin Med. 1995 Dec;71(6):355-7. Unique Identifier : AIDSLINE
       MED/96164963
 AB    OBJECTIVE--This study aimed to determine if patients with HIV infection
       can develop a significant antibody response to influenza immunisation,
       and whether such immunisation is detrimental to the progression of their
       HIV illness. DESIGN--Prospective, non-randomised study. METHODS--The
       titres of antibody response to influenza immunisation were determined in
       44 asymptomatic HIV positive men and compared with 16 HIV presumed
       seronegative controls. The magnitude of response were correlated with
       patients' CD4 lymphocyte counts. The rate of CD4 lymphocyte count
       decline over a median of 12 months before and after immunisation were
       also evaluated. RESULTS--Thirty-two of the 44 HIV positive subjects
       (73%) were able to mount a four-fold or greater response to at least one
       of the influenza strains, and 14 of them (32%) did so to all four
       strains. In comparison, 15 of the 16 controls (93.5%) had a four-fold or
       greater response to at least one, and six of them (38%) to all influenza
       strains, which was not significantly different from the HIV positive
       group. The magnitude of increase in antibody titre was not significantly
       different between the two groups either. CD4 lymphocyte count change for
       a median of 12 months after immunisation was not different from a median
       of 12 months before immunisation. CONCLUSIONS--Asymptomatic HIV infected
       patients are able to mount antibody response to influenza immunisation,
       which appears to be safe in respect to HIV illness progression in the
       short term.
 DE    Adolescence  Adult  Antibodies, Viral/BIOSYNTHESIS  CD4 Lymphocyte Count
       Human  HIV Infections/BLOOD/*IMMUNOLOGY
       Influenza/IMMUNOLOGY/*PREVENTION & CONTROL  Influenza
       Vaccine/*IMMUNOLOGY  Male  Middle Age  Prospective Studies  Vaccination
       JOURNAL ARTICLE

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