Document 0184
 DOCN  M9650184
 TI    Molecular pathogenesis of non-Hodgkin lymphoma: a clinical perspective.
 DT    9605
 AU    Gaidano G; Pastore C; Volpe G; Laboratorio di Medicina e Oncologia
       Molecolare, Ospedale San; Luigi Gonzaga, Universita di Torino, Orbassano
       (TO), Italy.
 SO    Haematologica. 1995 Sep-Oct;80(5):454-72. Unique Identifier : AIDSLINE
       MED/96058921
 AB    Despite a common origin from mature lymphoid cells, non-Hodgkin
       lymphomas (NHL) represent a surprisingly heterogeneous group of lymphoid
       malignancies whose classification is continuously being remodeled. The
       most recent proposal, the Revised European-American classification,
       introduces pathogenetic features among the classification criteria. In
       this respect, knowledge of the molecular pathogenesis of NHL, which is
       based upon genetic lesions leading to activation of proto-oncogenes
       (e.g. BCL-1, BCL-2, BCL-6, c-MYC) or disruption of tumor suppressor
       genes (e.g. p53), is becoming increasingly relevant for the clinician.
       These lesions combine into multiple molecular pathways which are
       selectively associated with distinct NHL types. Thus, for example,
       rearrangements of BCL-1, BCL-2, BCL-6, and c-MYC ar the genetic
       hallmarks of mantle cell, follicular, diffuse large cell, and Burkitt's
       lymphoma, respectively. Overall, from clinical perspective, NHL genetic
       lesions serve three purposes: a) they assist and complement histologic
       diagnosis; b) they provide a molecular marker with prognostic relevance;
       c) they allow evaluation of minimal residual disease through highly
       specific and highly sensitive technologies.
 DE    Cell Transformation, Viral  Chromosomes, Human/ULTRASTRUCTURE
       DNA-Binding Proteins/GENETICS  Gene Expression Regulation, Neoplastic
       Genes, myc  *Genes, Suppressor, Tumor  Herpesviridae Infections
       Herpesvirus 4, Human  Human  Lymphoma, AIDS-Related/GENETICS  Lymphoma,
       Non-Hodgkin's/CLASSIFICATION/*GENETICS/PATHOLOGY/  VIROLOGY
       Proto-Oncogene Proteins/GENETICS  *Proto-Oncogenes  Support, Non-U.S.
       Gov't  Transcription Factors/GENETICS  Translocation (Genetics)  Tumor
       Virus Infections  JOURNAL ARTICLE  REVIEW  REVIEW, ACADEMIC

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