Document 0194
 DOCN  M9650194
 TI    C-C chemokines, but not the C-X-C chemokines interleukin-8 and
       interferon-gamma inducible protein-10, stimulate transendothelial
       chemotaxis of T lymphocytes.
 DT    9605
 AU    Roth SJ; Carr MW; Springer TA; Center for Blood Research, Boston, MA
       02115, USA.
 SO    Eur J Immunol. 1995 Dec;25(12):3482-8. Unique Identifier : AIDSLINE
       MED/96140690
 AB    Eight chemokines were tested for ability to elicit transendothelial
       chemotaxis of unstimulated peripheral blood T lymphocytes. The C-C
       chemokines monocyte chemotactic protein (MCP)-2, MCP-3, RANTES,
       macrophage inflammatory protein (MIP)-1 alpha, MIP-1 beta, and, as
       previously described, MCP-1 induced significant, dose-dependent
       transendothelial chemotaxis of CD3+ T lymphocytes. In contrast, the
       C-X-C chemokines interleukin-8 (IL-8) and interferon-gamma inducible
       protein-10 (IP-10) failed to induce transendothelial chemotaxis of CD3+
       T lymphocytes or T lymphocyte subsets. RANTES, MIP-1 alpha, and MIP-1
       beta induced significant transendothelial chemotaxis of CD4+, CD8+, and
       CD45R0+ T lymphocyte subsets. Phenotyping of mononuclear cells that
       underwent transendothelial migration to MCP-2, MCP-3, RANTES, or MIP-1
       alpha showed both monocytes and activated (CD26 high), memory-type
       (CD45R0+) T cells. Both CD4+ and CD8+ T lymphocytes were recruited, but
       not natural killer cells or significant numbers of B cells. MCP-2 was
       the only C-C chemokine tested that attracted a significant number of
       naive-type (CD45RA+) T lymphocytes. In the absence of endothelium, IL-8
       but not IP-10 promoted modest but significant chemotoxis of CD3+ T
       lymphocytes. Our data support the hypothesis that C-C, not the C-X-C
       chemokines IL-8 or IP-10, promote transendothelial chemotaxis of T
       lymphocytes.
 DE    Antigens, CD3/PHYSIOLOGY  Antigens, CD45/PHYSIOLOGY
       Chemokines/CHEMISTRY/*PHARMACOLOGY  Chemotaxis, Leukocyte/*DRUG
       EFFECTS/IMMUNOLOGY  Cytokines/BIOSYNTHESIS/CHEMISTRY/*PHARMACOLOGY
       CD4-Positive T-Lymphocytes/PHYSIOLOGY  CD8-Positive
       T-Lymphocytes/PHYSIOLOGY  Endothelium, Vascular/*IMMUNOLOGY  Human
       Immunophenotyping  Interferon Type II/*PHARMACOLOGY
       Interleukin-8/CHEMISTRY/*PHARMACOLOGY  Membranes, Artificial  Monocyte
       Chemoattractant Proteins/PHARMACOLOGY  Support, U.S. Gov't, P.H.S.
       T-Lymphocyte Subsets/CLASSIFICATION/*PHYSIOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).