Document 0196
 DOCN  M9650196
 TI    CD14lowCD16high: a cytokine-producing monocyte subset which expands
       during human immunodeficiency virus infection.
 DT    9605
 AU    Thieblemont N; Weiss L; Sadeghi HM; Estcourt C; Haeffner-Cavaillon N;
       Laboratory of Immunopathology, INSERM U430, Hopital Broussais,; Paris,
       France.
 SO    Eur J Immunol. 1995 Dec;25(12):3418-24. Unique Identifier : AIDSLINE
       MED/96140681
 AB    Infection with the human immunodeficiency virus HIV-1 is associated with
       the expansion of a CD14lowCD16high monocyte subset in peripheral blood.
       This subset, which represents a minor subpopulation of monocytes in
       healthy individuals, increases during HIV infection and, in patients
       with AIDS, may represent up to 40% of the total circulating monocyte
       cell population. The CD14lowCD16high circulating monocytes co-express
       MAX.1, p150,95 and HLA-DR which are typical of tissue macrophage
       markers. These cells also express higher levels of intracellular
       interleukin (IL)-1 alpha and tumor necrosis factor (TNF)-alpha than the
       CD14highCD16low monocyte population from the same patients. The
       CD14lowCD16high cells also express low levels of CD35, CD11a and CD4 in
       common with normal monocytes. When cultured in vitro, monocytes from
       HIV-seropositive individuals differentiated within a few hours into an
       elongated fibroblastoid shape characteristic of migratory cells. Our
       results suggest that the expansion of the CD14lowCD16high monocyte
       subset, which produce high amount sof TNF-alpha and IL-1 alpha, may
       participate in the immune dysfunction observed during HIV infection.
 DE    *Antigens, CD14/ANALYSIS  Cell Division/IMMUNOLOGY  Human  HIV
       Infections/*IMMUNOLOGY  HIV Seronegativity/IMMUNOLOGY  HIV
       Seropositivity/IMMUNOLOGY  HIV-1/*IMMUNOLOGY  Immunophenotyping
       Interleukin-1/BIOSYNTHESIS
       Monocytes/CLASSIFICATION/*CYTOLOGY/*METABOLISM  *Receptors, IgG/ANALYSIS
       Support, Non-U.S. Gov't  Tumor Necrosis Factor/BIOSYNTHESIS  JOURNAL
       ARTICLE

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