Document 0208
 DOCN  M9650208
 TI    Cutaneous Acanthamoeba infection in the acquired immunodeficiency
       syndrome: response to multidrug therapy.
 DT    9605
 AU    Hunt SJ; Reed SL; Mathews WC; Torian B; University of California San
       Diego Medical Center, USA.
 SO    Cutis. 1995 Nov;56(5):285-7. Unique Identifier : AIDSLINE MED/96157427
 AB    Acanthamoeba, a free-living ameba of soil and water, produces the rare
       infections of granulomatous amebic encephalitis and amebic keratitis. We
       report a 38-year-old white man with the acquired immunodeficiency
       syndrome (AIDS) who experienced Acanthamoeba infection that presented as
       multiple skin nodules without associated encephalitis. Histologic
       examination revealed necrotizing granulomatous inflammation with
       numerous amebic organisms that were cultured and identified as
       Acanthamoeba group 2, probably Acanthamoeba castellani by monoclonal
       antibodies. Results of in vitro susceptibility testing demonstrated
       resistance to all six tested drugs. A partial clinical response,
       however, was obtained with multidrug therapy.
 DE    *Acanthamoeba/CLASSIFICATION  Adult  Amebiasis/*DRUG THERAPY
       Amebicides/ADMINISTRATION & DOSAGE/*THERAPEUTIC USE  Amphotericin
       B/ADMINISTRATION & DOSAGE/THERAPEUTIC USE  Animal  Antibiotics,
       Macrolide/ADMINISTRATION & DOSAGE/THERAPEUTIC USE
       Antimetabolites/ADMINISTRATION & DOSAGE/THERAPEUTIC USE  AIDS-Related
       Opportunistic Infections/*DRUG THERAPY  Case Report  Drug Therapy,
       Combination  Flucytosine/ADMINISTRATION & DOSAGE/THERAPEUTIC USE  Human
       Male  Rifampin/ADMINISTRATION & DOSAGE/THERAPEUTIC USE  Skin Diseases,
       Parasitic/*DRUG THERAPY  JOURNAL ARTICLE

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