Document 0216
 DOCN  M9650216
 TI    Immune dysregulation in Ethiopian immigrants in Israel: relevance to
       helminth infections?
 DT    9605
 AU    Bentwich Z; Weisman Z; Moroz C; Bar-Yehuda S; Kalinkovich A; R. Ben-Ari
       Institute of Clinical Immunology, Kaplan Hospital,; Hebrew University
       Hadassah Medical School, Rehovot, Israel.
 SO    Clin Exp Immunol. 1996 Feb;103(2):239-43. Unique Identifier : AIDSLINE
       MED/96152671
 AB    The infectious disease background and particularly the helminth
       infections that are endemic in Africa could have profound effects on the
       host immune system. Studies that we have performed on an Ethiopian HIV-
       immigrant population that has recently reached Israel, lend support to
       this notion. They have indeed revealed a very high prevalence of
       helminth and several other infections with an extreme immune
       dysregulation, consisting of: (i) highly elevated plasma IgE, IgG,
       placental isoferritin, p75 soluble TNF receptor (sTNFR) levels and very
       high blood eosinophilia; (ii) increased secretion from
       phytohaemagglutinin (PHA)-simulated peripheral blood mononuclear cells
       (PBMC) of the cytokines IL-2, IL-4, IL-10 and p75 sTNFR, and decreased
       secretion of interferon-gamma (IFN-gamma) and IL-6; (iii) increased and
       decreased surface expression of p75 TNFR and IL-6 receptor on
       lymphocytes, respectively. The causal relationship between this immune
       dysregulation and the infectious background is highly suggestive, and
       could have far-reaching implications in the resistance to other
       infections.
 DE    Blacks  Cells, Cultured  Cytokines/*BIOSYNTHESIS  Ethiopia/ETHNOLOGY
       Helminthiasis/ETHNOLOGY/*IMMUNOLOGY  Human  Immunoglobulins/BLOOD
       Immunologic Diseases/ETHNOLOGY/EPIDEMIOLOGY/*PARASITOLOGY
       Israel/EPIDEMIOLOGY  Leukocytes, Mononuclear/*IMMUNOLOGY/PATHOLOGY
       Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).