Document 0220
 DOCN  M9650220
 TI    Gamma delta T lymphocyte responses to HIV.
 DT    9605
 AU    Wallace M; Bartz SR; Chang WL; Mackenzie DA; Pauza CD; Malkovsky M;
       Department of Medical Microbiology and Immunology, University of;
       Wisconsin Medical School, Madison, USA.
 SO    Clin Exp Immunol. 1996 Feb;103(2):177-84. Unique Identifier : AIDSLINE
       MED/96152662
 AB    Natural immunity may be involved in controlling viral spread in hosts
       infected with HIV. A panel of gamma delta T cell receptor-positive
       lymphocyte clones was isolated from the peripheral blood of healthy HIV-
       donors and tested for anti-HIV cytotoxic responses. Twelve of 30 (40%) V
       gamma 9+/V delta 2+ T cell clones, but none of seven V delta 1+ T cell
       clones, displayed lytic activity against HIV-infected cells. The V gamma
       9+/V delta 2+ clones cytotoxic for HIV-infected cells also lysed Daudi
       cells. However, not all V gamma 9+/V delta 2+ clones which lysed Daudi
       targets had the capacity to lyse HIV-infected cells. Some of the gamma
       delta T cell clones were also investigated for potential proliferative
       responses to HIV-infected cells. One V gamma 9+/V delta 2+ T cell clone
       (ME8-7) and one V delta 1+ T cell clone (ME18-2) demonstrated
       proliferative responses towards HIV-infected cells. Another V gamma 9+/V
       delta 2+ clone (VM39) proliferated in response to cell-free HIV. Taken
       together, these results provide direct evidence of anti-HIV gamma delta
       T cell responses in healthy, HIV- persons.
 DE    Clone Cells  *Cytotoxicity, Immunologic  Human  HIV
       Infections/*IMMUNOLOGY  HIV-1/*IMMUNOLOGY  Receptors, Antigen, T-Cell,
       gamma-delta/*IMMUNOLOGY  Support, Non-U.S. Gov't  Support, U.S. Gov't,
       P.H.S.  T-Lymphocyte Subsets  T-Lymphocytes/*IMMUNOLOGY/VIROLOGY
       JOURNAL ARTICLE

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