Document 0222
 DOCN  M9650222
 TI    Generalized immune activation in pulmonary tuberculosis: co-activation
       with HIV infection.
 DT    9605
 AU    Vanham G; Edmonds K; Qing L; Hom D; Toossi Z; Jones B; Daley CL; Huebner
       B; Kestens L; Gigase P; Ellner JJ; Department of Infection and Immunity,
       Institute of Tropical; Medicine, Antwerpen, Belgium.
 SO    Clin Exp Immunol. 1996 Jan;103(1):30-4. Unique Identifier : AIDSLINE
       MED/96150278
 AB    Parameters of immune activation/differentiation were studied in a group
       of newly diagnosed HIV- and HIV+ pulmonary tuberculosis (TB) patients.
       Compared with controls, HLA-DR expression on both CD4 and CD8 T cells
       from the HIV- TB patients was approximately doubled; HLA-DR on T cells
       from the HIV+ group was tripled. The monocytes from both groups of
       patients expressed abnormally high levels of the Fc gamma receptors I
       and III. Serum levels of tumour necrosis factor-alpha (TNF-alpha),
       neopterin and beta 2-microglobulin were increased in HIV- and even more
       so in HIV+ TB patients. The expression of HLA-DR on T cell subsets and
       of Fc gamma R on monocytes correlated with each other, but not with
       serum activation markers. This pattern of non-specific activation during
       TB infection may be associated with enhanced susceptibility to HIV
       infection.
 DE    Adult  Aged  Antigens, Differentiation, T-Lymphocyte/*BIOSYNTHESIS
       Biological Markers/ANALYSIS  Female  Human  HIV
       Infections/COMPLICATIONS/*IMMUNOLOGY  HIV Seronegativity  HLA-DR
       Antigens/BIOSYNTHESIS  Male  Middle Age  Monocytes/METABOLISM
       Receptors, Fc/BIOSYNTHESIS  Support, Non-U.S. Gov't  Support, U.S.
       Gov't, Non-P.H.S.  Support, U.S. Gov't, P.H.S.  T-Lymphocytes/METABOLISM
       Tuberculosis, Pulmonary/COMPLICATIONS/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).