Document 0244
 DOCN  M9650244
 TI    Synthesis and antiviral effects of 2-heteroaryl substituted adenosine
       and 8-heteroaryl substituted guanosine derivatives.
 DT    9605
 AU    Persson T; Gronowitz S; Hornfeldt AB; Johansson NG; Chemical Center,
       Lund, Sweden.
 SO    Bioorg Med Chem. 1995 Oct;3(10):1377-82. Unique Identifier : AIDSLINE
       MED/96120458
 AB    2-(2- and 3-Thienyl)adenosine and the corresponding furyl derivatives
       were prepared though Pd(0)-catalyzed coupling of
       2',3',5'-tri-O-(t-butyldimethylsilyl)-2-iodoadenosine with the
       appropriate tributyltin derivatives followed by deprotection.
       Preparation of the 8-(2- and 3-thienyl)guanosines and 8-(2- and
       3-furyl)guanosines followed a similar route. Antiviral properties of
       these compounds and the related 2,6-diaminopurine ribofuranosides were
       of no pharmacological interest.
 DE    Adenosine/*ANALOGS & DERIVATIVES/CHEMICAL SYNTHESIS/*PHARMACOLOGY
       Antiviral Agents/CHEMICAL SYNTHESIS/*PHARMACOLOGY  Cell Division/DRUG
       EFFECTS  Cell Line  Enzyme-Linked Immunosorbent Assay
       Guanosine/*ANALOGS & DERIVATIVES/CHEMICAL SYNTHESIS/*PHARMACOLOGY
       Herpesvirus 1, Human/DRUG EFFECTS  Human  HIV-1/DRUG EFFECTS  Nuclear
       Magnetic Resonance  Orthomyxovirus Type A, Human/DRUG EFFECTS  Support,
       Non-U.S. Gov't  Virus Replication/DRUG EFFECTS  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).