Document 0245
 DOCN  M9650245
 TI    Anti-AIDS agents--XIX. Neotripterifordin, a novel anti-HIV principle
       from Tripterygium wilfordii: isolation and structural elucidation.
 DT    9605
 AU    Chen K; Shi Q; Fujioka T; Nakano T; Hu CQ; Jin JQ; Kilkuskie RE; Lee KH;
       Natural Products Laboratory, School of Pharmacy, University of; North
       Carolina, Chapel Hill 27599, USA.
 SO    Bioorg Med Chem. 1995 Oct;3(10):1345-8. Unique Identifier : AIDSLINE
       MED/96120454
 AB    A new kaurane type diterpene lactone, neotripterifordin (1), has been
       isolated from the roots of Tripterygium wilfordii. The structure of 1
       was elucidated by spectroscopic methods, which included the concerted
       application of a number of 2-D NMR techniques including 1H-1H COSY,
       phase-sensitive NOESY, HETCOR, and long-range HETCOR. Compound 1 showed
       potent anti-HIV replication activity in H9 lymphocyte cells with an EC50
       of 25 nM and TI of 125.
 DE    Animal  Antiviral Agents/*ISOLATION & PURIF/*PHARMACOLOGY  Cattle
       Cells, Cultured  China  Diterpenes/*ISOLATION & PURIF/PHARMACOLOGY
       Human  HIV-1/*DRUG EFFECTS  Lymphocytes/DRUG EFFECTS/VIROLOGY  Plant
       Extracts/CHEMISTRY/PHARMACOLOGY  Plant Roots/CHEMISTRY  Plants,
       Toxic/*CHEMISTRY  Spectrophotometry, Infrared  Spectrum Analysis, Mass
       Support, U.S. Gov't, P.H.S.  Virus Replication/DRUG EFFECTS  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).