Document 0258
 DOCN  M9650258
 TI    Comparison of immunodeficiency and AIDS defining conditions in HIV
       negative and HIV positive men with haemophilia A [see comments]
 DT    9605
 AU    Sabin CA; Pasi KJ; Phillips AN; Lilley P; Bofill M; Lee CA; Department
       of Public Health, Royal Free Hospital School of; Medicine, London.
 SO    BMJ. 1996 Jan 27;312(7025):207-10. Unique Identifier : AIDSLINE
       MED/96160276
 CM    Comment in: BMJ 1996 Jan 27;312(7025):210-1
 AB    OBJECTIVE--To investigate the hypothesis that high usage of clotting
       factor concentrate, rather than HIV infection, is the cause of
       immunodeficiency and AIDS in men with haemophilia. DESIGN--A comparison
       of AIDS defining conditions and CD4 counts in HIV positive and HIV
       negative patients with haemophilia matched for usage of clotting factor
       concentrate. SETTING--A comprehensive care haemophilia centre.
       SUBJECTS--17 HIV positive and 17 HIV negative male patients with
       haemophilia A (age range 12-60 at beginning of study period) who had
       received similar amounts of clotting factor concentrate yearly over the
       years 1980-90. MAIN OUTCOME MEASURES--Clinical events listed as AIDS
       defining in the Centers for Disease Control AIDS definition; CD4
       lymphocyte counts; death. RESULTS--Of 108 HIV positive male patients
       with haemophilia A, only 17 could be matched to an HIV negative patient.
       This was due to the much higher average usage of factor VIII in the HIV
       positive group. Between 1980 and 1990, 16 clinical events occurred in
       nine of the 17 HIV positive patients. No event occurred in the 17 HIV
       negative patients. In each pair the mean CD4 count during follow up was,
       on average, 0.5 x 10(9)/l lower in the HIV positive patient.
       CONCLUSION--These data reject the hypothesis that high usage of clotting
       factor concentrate, rather than HIV infection, is the cause of
       immunodeficiency and AIDS in men with haemophilia.
 DE    Acquired Immunodeficiency Syndrome/DRUG THERAPY/ETIOLOGY  Adolescence
       Adult  Comparative Study  CD4 Lymphocyte Count  Factor VIII/ADVERSE
       EFFECTS/*THERAPEUTIC USE  Hemophilia/*COMPLICATIONS/THERAPY  Human  HIV
       Seronegativity  HIV Seropositivity  Immunologic Deficiency
       Syndromes/*ETIOLOGY  Male  Middle Age  Support, Non-U.S. Gov't
       Zidovudine/ADVERSE EFFECTS/THERAPEUTIC USE  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).