Document 0262
 DOCN  M9650262
 TI    [Selective inhibition of replication of human cytomegalovirus by
       desferrioxamine in vitro and in vivo (case report)]
 DT    9605
 AU    Gumbel H; Cinatl J Jr; Rabenau H; Vogel JU; Doerr HW; Ohrloff C; Zentrum
       der Augenheilkunde, Universitat Frankfurt/Main.
 SO    Ophthalmologe. 1995 Dec;92(6):840-3. Unique Identifier : AIDSLINE
       MED/96147378
 AB    In AIDS patients cytomegalovirus (HCMV) retinitis is one of the most
       frequent opportunistic infections. Antiviral therapy aims at preserving
       vision as long as possible, but more and more HCMV isolates are proving
       to be resistant to ganciclovir (GCV) and foscarnet (PFA) in vitro. We
       tested whether desferrioxamine (DFO), an iron chelator with antiherpetic
       activity, can inhibit clinical virus isolates and laboratory strains.
       Clinical isolates were obtained from urine samples of AIDS patients with
       HCMV retinitis. The concentrations of DFO required for 50% and 90%
       reduction of the production of HCMV in several HCMV strains ranged from
       3.1 to 4.9 microns and from 14.2 to 17.3 microns, respectively,
       Inhibitory effects of DFO on HCMV replication were completely prevented
       by co-incubation with stoichiometric amounts of FE3+. CASE REPORTS: DFO
       was administered by daily dose of 1 g i.v. to a patient with AIDS in
       whom HCMV retinitis continued to progress despite combination therapy
       with GCV and PFA. The addition of DFO to the combination inhibited
       progression of the disease. No relapse of HCMV retinitis was seen with 3
       months of DFO therapy. The treatment was free of side effects.
 DE    Adult  Antiviral Agents/ADMINISTRATION & DOSAGE  AIDS-Related
       Opportunistic Infections/*DRUG THERAPY/VIROLOGY  Case Report
       Cytomegalovirus/*DRUG EFFECTS  Cytomegalovirus Retinitis/*DRUG
       THERAPY/VIROLOGY  Deferoxamine/*ADMINISTRATION & DOSAGE  Dose-Response
       Relationship, Drug  English Abstract  Ganciclovir/ADMINISTRATION &
       DOSAGE  Human  Infusions, Intravenous  Male
       Siderophores/*ADMINISTRATION & DOSAGE  Virus Cultivation  Virus
       Replication/*DRUG EFFECTS  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).