Document 0268
 DOCN  M9650268
 TI    Human T lymphotropic virus type I (HTLV-I)-associated
       myelopathy/tropical spastic paraparesis (HAM/TSP): recent perspectives.
 DT    9605
 AU    Ijichi S; Osame M; Third Department of Internal Medicine, Faculty of
       Medicine,; Kagoshima University.
 SO    Intern Med. 1995 Aug;34(8):713-21. Unique Identifier : AIDSLINE
       MED/96085862
 AB    Human T lymphotropic virus type I (HTLV-I)-associated
       myelopathy/tropical spastic paraparesis (HAM/TSP) is a well-defined
       clinicopathological entity, and approximately 1,900 patients with
       HAM/TSP have been reported in the world. Improved polymerase chain
       reaction (PCR)-based in situ techniques have allowed a better
       appreciation of the cellular localization of the virus activation in
       infected patients, and there is accumulating evidence that HAM/TSP is
       characterized by a distributional bias of viral activation between the
       blood flow and central nervous system (CNS). This review summarizes the
       current status of our understanding of HAM/TSP, and emphasizes the
       possible pathogenic involvement of cellular interactions between
       infected cells and responding immunocompetent cells in the CNS of
       patients with HAM/TSP. In addition, the notable systemic manifestations
       with or without myelopathy in HTLV-I-infected individuals are described.
 DE    Human  *Paraparesis, Tropical Spastic/DIAGNOSIS/EPIDEMIOLOGY/VIROLOGY
       JOURNAL ARTICLE  REVIEW  REVIEW, ACADEMIC

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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