Document 0271
 DOCN  M9650271
 TI    Varied effects of thoracic irradiation on peripheral lymphocyte subsets
       in lung cancer patients.
 DT    9605
 AU    Nakayama Y; Makino S; Fukuda Y; Min KY; Ikemoto T; Shimizu A; Ohsawa N;
       First Department of Internal Medicine, Osaka Medical College,;
       Takatsuki.
 SO    Intern Med. 1995 Oct;34(10):959-65. Unique Identifier : AIDSLINE
       MED/96157626
 AB    To investigate the influence of thoracic irradiation on immunological
       competence in patients with lung cancer, we examined the changes in
       peripheral blood lymphocyte subsets in 15 patients before and after
       radiation therapy by two-color flow cytometry techniques. After
       radiation therapy, the percentage and the absolute number of CD4+CD45RA+
       cells (naive T cells) and CD56+ and/or CD16+ cells (NK cells) decreased.
       The percentage of CD4+human leukocyte antigen-DR(HLA-DR)+ cells
       (activated CD4T cells) and CD8+HLA-DR+ cells (activated CD8T cells)
       increased, although the absolute number did not change significantly.
       Naive T cells may be more selectively damaged than memory T cells by
       thoracic irradiation, through their recirculation behavior. The
       reduction of natural killer (NK) cells is disadvantageous for anti-tumor
       immunity. The percentage of HLA-DR positive T lymphocytes was
       significantly increased, and thus the possibility of HLA-DR enhancement
       by irradiation cannot be excluded. Therefore, thoracic irradiation has
       numerous varied effects on the immunological system of lung cancer
       patients.
 DE    Adult  Aged  Antineoplastic Agents, Combined/PHARMACOLOGY/THERAPEUTIC
       USE  Combined Modality Therapy  CD4-Positive T-Lymphocytes/RADIATION
       EFFECTS  CD8-Positive T-Lymphocytes/RADIATION EFFECTS  Female  Flow
       Cytometry/METHODS  Human  HLA-DR Antigens/IMMUNOLOGY  Killer Cells,
       Natural/IMMUNOLOGY/RADIATION EFFECTS  Lung Neoplasms/DRUG
       THERAPY/IMMUNOLOGY/PATHOLOGY/*RADIOTHERAPY  Lymphocyte Count/DRUG
       EFFECTS/RADIATION EFFECTS  Lymphocyte Subsets/DRUG
       EFFECTS/IMMUNOLOGY/*RADIATION EFFECTS  Male  Middle Age  Neoplasm
       Staging  T-Lymphocytes/IMMUNOLOGY/RADIATION EFFECTS  JOURNAL ARTICLE

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