Document 0272
 DOCN  M9650272
 TI    Adult T-cell leukemia.
 DT    9605
 AU    Takatsuki K; Second Department of Internal Medicine, Kumamoto
       University; School of Medicine.
 SO    Intern Med. 1995 Oct;34(10):947-52. Unique Identifier : AIDSLINE
       MED/96157624
 AB    Adult T-cell leukemia (ATL) was first reported in Japan, where it has a
       high incidence in the southwestern region. The retrovirus, human
       T-lymphotropic virus type I (HTLV-I), is the causative agent of ATL. In
       ATL-endemic areas, the rate of HTLV-I carriers is high. A definite
       diagnosis of ATL is based on the presence of HTLV-I proviral DNA in the
       tumor cell DNA. ATL cells originate from the CD4 subset of peripheral T
       cells. ATL shows diverse clinical features but can be divided into four
       subtypes:acute, chronic, smoldering, and lymphoma type. Chemotherapy is
       not effective; the acute and lymphoma types have a poor prognosis.
       Familial occurrence of ATL is common. HTLV-I infection is caused by
       transmission of live infected lymphocytes from mother to child, from man
       to woman, or by blood transfusion. Infection with HTLV-I can lead to
       other diseases, including HTLV-I-associated myelopathy/tropical spastic
       paraparesis and HTLV-I uveitis.
 DE    Adult  Aged  Aged, 80 and over  Child  Disease Transmission, Vertical
       Female  Human  HTLV-I/ISOLATION & PURIF  HTLV-I
       Infections/DIAGNOSIS/EPIDEMIOLOGY/THERAPY/*TRANSMISSION  Incidence
       Infant, Newborn  Japan/EPIDEMIOLOGY  Leukemia,
       T-Cell/*DIAGNOSIS/EPIDEMIOLOGY/THERAPY/*VIROLOGY  Male  Middle Age
       JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

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