Document 0275
 DOCN  M9650275
 TI    Cytokines in the acquired immunodeficiency syndrome and other infectious
       diseases.
 DT    9605
 AU    Poli G; Vicenzi E; Ghezzi S; Lazzarin A; Department of Infectious
       Diseases, San Raffaele Hospital and; Scientific Institute, IRCCS, Milan,
       Italy.
 SO    Int J Clin Lab Res. 1995;25(3):128-34. Unique Identifier : AIDSLINE
       MED/96121690
 AB    The pathogenesis of several infectious diseases is frequently related
       not only to their etiological agents of viral, bacterial, or parasitic
       nature, but also to the host immune response. Both inflammatory
       responses and specific immune responses to the invading microorganisms
       are controlled by complex networks of intercellular signalling
       molecules, namely cytokines. This rapidly growing family of mediators
       includes lymphokines, interleukins, and molecules such as tumor necrosis
       factors and interferons. Patterns of cytokine production from antigen-
       or allergen-specific T lymphocytic cell clones have been identified,
       firstly in animal models and subsequently in man, and are commonly
       referred to as TH0, TH1, and TH2 profiles. The predominance of one of
       these profiles strongly influences the type of immune response (humoral
       versus cellular) and, at least in some experimental models, whether the
       immune response is protective or harmful. This is most convincingly
       demonstrated in models of parasitic diseases, but has also been
       hypothesized to be involved in the pathogenesis of human
       immunodeficiency virus infection and the acquired immunodeficiency
       syndrome. Earlier studies on human immunodeficiency virus infection
       revealed that the replicative capacity of this retrovirus, like the
       herpes viruses, is strongly influenced by the cytokine milieu of
       infected cells. Transcriptional and post-transcriptional regulation of
       human immunodeficiency virus expression by human cytokines are examples
       of the complex interdigitation of viruses with the host immune system.
 DE    Acquired Immunodeficiency Syndrome/*IMMUNOLOGY  Animal  Communicable
       Diseases/IMMUNOLOGY  Cytokines/*IMMUNOLOGY  Human  Support, Non-U.S.
       Gov't  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).