Document 0281
 DOCN  M9650281
 TI    The growth of human HIV-1 infected U937 cells in immune-deprived mice.
 DT    9605
 AU    Chernukhin IV; Chepurnov AA; Gaidul KV; Siberian Branch of the Russian
       Academy of Medical Sciences,; Novosibirsk, Russia.
 SO    Biomed Pharmacother. 1995;49(7-8):358-63. Unique Identifier : AIDSLINE
       MED/96145528
 AB    We report in vivo growth of human promonocytic cells infected with HIV-1
       presented in new mouse model. Cloned U937 cells chronically infected
       with HIV-1 were grafted in (CBA*C57B1/6)F1 mice deprived of immunity by
       thymectomia and total body irradiation with subsequent marrow
       reconstitution. Nine weeks after cell inoculation, HIV-1-positive cells
       were found only in mice that received an additional single dose of
       cyclophosphamide (100 mg/kg bw) prior to transplantation, whereas, in
       mice without further immune deprivation, the complete elimination of
       cells bearing viral antigen occurred already on the seventh day after
       transplantation. The approach described may be suitable for in vivo
       development of antiviral drugs against latent infection in
       macrophage-like cells which represent a serious problem in therapy of
       AIDS in humans.
 DE    Animal  Cell Division  Cell Line  Chronic Disease  *Disease Models,
       Animal  Female  Human  HIV Infections/*IMMUNOLOGY/*PATHOLOGY  *HIV-1
       Immunocompromised Host  Lymphoma, Large-Cell/PATHOLOGY  Mice  Mice,
       Inbred CBA  Mice, Inbred C57BL  JOURNAL ARTICLE

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