Document 0288
 DOCN  M9650288
 TI    Clinical spectrum of herpes zoster in adults infected with human
       immunodeficiency virus.
 DT    9605
 AU    Glesby MJ; Moore RD; Chaisson RE; Department of Medicine, Johns Hopkins
       University, School of; Medicine, Baltimore, Maryland 21205, USA.
 SO    Clin Infect Dis. 1995 Aug;21(2):370-5. Unique Identifier : AIDSLINE
       MED/96002792
 AB    To determine the incidence and clinical manifestations of herpes zoster
       in a hospital-based clinic for adults infected with human
       immunodeficiency virus (HIV), we reviewed the records of all patients
       for whom zoster was diagnosed at or after their first clinic visit.
       Fifty-two episodes of zoster occurred in 45 patients during 1,614
       person-years of follow-up (incidence, 3.2 episodes per 100
       person-years). The following major complications of zoster occurred in
       12 patients (27%): ocular complications (5), neurological complications
       (4), and chronic atypical skin lesions (5). Six patients each had
       postherpetic neuralgia and bacterial superinfection, which were the
       common minor complications of zoster. Multivariate analysis revealed
       that only a low CD4 cell count (< or = 200/mm3) was predictive of a
       major complication of zoster (OR, 13.2; 95% CI, 1.52-114; P = .019).
       Thus, complications of herpes zoster are common in patients with HIV
       infection, especially those with advanced immunosuppression.
 DE    Adult  Ambulatory Care Facilities  Baltimore/EPIDEMIOLOGY  Cohort
       Studies  CD4 Lymphocyte Count  Female  Follow-Up Studies  Herpes
       Zoster/DIAGNOSIS/*EPIDEMIOLOGY/ETIOLOGY  Human  HIV
       Infections/*COMPLICATIONS/IMMUNOLOGY  *HIV-1  Incidence  Male  Middle
       Age  Recurrence  Retrospective Studies  Risk Factors  Support, U.S.
       Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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