Document 0297
 DOCN  M9650297
 TI    Primary central nervous system lymphoma: treatment with chemotherapy and
       radiotherapy.
 DT    9605
 AU    Sarazin M; Ameri A; Monjour A; Nibio A; Poisson M; Delattre JY;
       Department of Neurology, Hopital de la Salpetriere, Paris,; France.
 SO    Eur J Cancer. 1995 Nov;31A(12):2003-7. Unique Identifier : AIDSLINE
       MED/96164933
 AB    Between 1989 and 1993, 22 HIV negative patients with primary central
       nervous system lymphoma (PCNLS) were treated with three different
       regimens. In group A, 13 patients received preradiotherapy systemic and
       intrathecal methotrexate (MTX), radiotherapy (RT) and three courses of
       post-RT chemotherapy (CT) with thiotepa and procarbazine. In group B, 4
       patients received a similar CT only after RT and without intrathecal MTX
       in 3/4 cases. In group C, 5 elderly patients received CT alone. In group
       A, 9/13 patients achieved response after pre-RT CT and 12/13 were in
       complete response (CR) after RT. After a median follow-up of 27 months,
       8/13 (62%) patients are alive but 4 have leucoencephalopathy and
       cognitive dysfunction. In group B, all 4 patients were in CR after RT
       but the 3 patients who did not receive intrathecal MTX died within 10
       months with meningeal recurrence. In group C, 4/5 patients had a
       response to CT. 2 patients died of recurrent tumour at 5 and 10 months,
       and 2 are living in CR 11+ and 21+ months after diagnosis, 1 after
       salvage CT. Combined treatment with RT and CT is useful in PCNSL but
       adequate treatment of the meninges is required. CT alone is sometimes of
       value in elderly patients in whom RT is not indicated.
 DE    Adult  Aged  Aged, 80 and over  Antineoplastic Agents, Combined/ADVERSE
       EFFECTS/THERAPEUTIC USE  Brain Neoplasms/*DRUG THERAPY/*RADIOTHERAPY
       Combined Modality Therapy  Drug Administration Schedule  Female
       Follow-Up Studies  Human  Lymphoma, Non-Hodgkin's/*DRUG
       THERAPY/*RADIOTHERAPY  Male  Middle Age  Recurrence  Retrospective
       Studies  Support, Non-U.S. Gov't  Treatment Outcome  JOURNAL ARTICLE

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