Document 0320
 DOCN  M9650320
 TI    Acceptability of HIV vaccine trials in high-risk heterosexual cohorts in
       Mombasa, Kenya.
 DT    9605
 AU    Jackson DJ; Martin HL Jr; Bwayo JJ; Nyange PM; Rakwar JP; Kashonga F;
       Mandaliya K; Ndinya-Achola JO; Kreiss JK; Department of Epidemiology,
       University of Washington, Seattle; 98104-2499, USA.
 SO    AIDS. 1995 Nov;9(11):1279-83. Unique Identifier : AIDSLINE MED/96126183
 AB    OBJECTIVES: To ascertain the level of acceptance of a prophylactic HIV
       vaccine trial in high-risk HIV-seronegative heterosexual cohorts of men
       and women in Mombasa, Kenya, and to assess the anticipated effects of
       participation on risk behavior. METHODS: Standardized questionnaire
       administered to a convenience sample of commercial sex workers and
       trucking company employees enrolled in prospective cohort studies.
       RESULTS: Ninety-six per cent of respondents believed that HIV was a
       major problem in Kenya and 86% of men and 94% of women perceived
       themselves at risk. One hundred per cent of women and 84% of men
       expressed interest in participation in an HIV vaccine trial, after
       explanation of the experimental nature of the vaccine, double-blind
       placebo-controlled design, prolonged follow-up and potential change in
       serostatus. Seventeen per cent of men and 9% of women anticipated an
       increase in risk behavior as a result of participation. CONCLUSION: The
       majority of individuals in two high-risk cohorts were interested in
       participating in Phase III efficacy trials of HIV vaccines. A
       significant minority anticipated an increase in risk behavior, which
       emphasizes the need for intensive counseling and education throughout a
       vaccine trial.
 DE    Adolescence  Adult  AIDS Vaccines/*THERAPEUTIC USE  Cohort Studies
       Double-Blind Method  Female  Human  HIV Infections/*PREVENTION &
       CONTROL/PSYCHOLOGY  HIV Seronegativity  Kenya  Male  Middle Age
       Questionnaires  Risk Factors  Sex Behavior  Support, U.S. Gov't, P.H.S.
       CLINICAL TRIAL  JOURNAL ARTICLE  RANDOMIZED CONTROLLED TRIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).