Document 0336
 DOCN  M9650336
 TI    Effects of prenatal ethanol exposure and stress in adulthood on
       lymphocyte populations in rats.
 DT    9605
 AU    Giberson PK; Weinberg J; Department of Anatomy, University of British
       Columbia, Vancouver,; Canada.
 SO    Alcohol Clin Exp Res. 1995 Oct;19(5):1286-94. Unique Identifier :
       AIDSLINE MED/96119388
 AB    The present study was undertaken to assess the possible interactive
       effects of prenatal ethanol exposure and stress in adulthood on
       lymphocyte populations in rat offspring, and to examine differential
       vulnerability of males and females to these challenges. Male and female
       offspring from prenatal ethanol-exposed (E), pair-fed, and ad
       libitum-fed control conditions were exposed to a 3-week chronic
       intermittent stress regimen in adulthood. Animals were exposed to two of
       six different stressors daily, one each at random times in the morning
       and afternoon, with the same pair of stressors being repeated every 4
       days. Following the 3-week stress period, lymphocytes from four
       compartments (peripheral blood, spleen, thymus, and cervical lymph
       nodes) were analyzed for expression of differentiation antigens. Data
       demonstrate that, whereas a number of the effects of prenatal ethanol on
       lymphocyte populations appeared to be nutritionally mediated, the
       additional challenge of exposure to stressors differentially affected
       animals exposed to ethanol prenatally and appeared to have effects
       primarily in male offspring. Stressed E males had a greater reduction in
       the number of pan T-cells in the thymus and peripheral blood, compared
       with nonstressed E males, but showed an increased peripheral blood pan
       T-antigen expression. Stressed E males also had reduced numbers of
       peripheral blood CD4+ T-cells and thymic CD4+CD8+ T-cells, compared with
       controls.(ABSTRACT TRUNCATED AT 250 WORDS)
 DE    Alcohol, Ethyl/*TOXICITY  Animal  CD4-CD8 Ratio/DRUG EFFECTS  Female
       Fetal Alcohol Syndrome/*IMMUNOLOGY  Immune Tolerance/DRUG
       EFFECTS/IMMUNOLOGY  Lymphocyte Subsets/*DRUG EFFECTS/IMMUNOLOGY  Male
       Pregnancy  *Prenatal Exposure Delayed Effects  Rats  Rats,
       Sprague-Dawley  Reference Values  Sex Characteristics  Stress,
       Psychological/*COMPLICATIONS/IMMUNOLOGY  Support, Non-U.S. Gov't
       Support, U.S. Gov't, P.H.S.  T-Lymphocyte Subsets/DRUG
       EFFECTS/IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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