Document 0342
 DOCN  M9650342
 TI    Temporal trends of initial CD4 cell counts following human
       immunodeficiency virus seroconversion in Italy, 1985-1992. The Human
       Immunodeficiency Virus Italian Seroconversion Study.
 DT    9605
 AU    Galai N; Lepri AC; Vlahov D; Pezzotti P; Sinicco A; Rezza G; Department
       of Epidemiology, School of Hygiene and Public Health,; Johns Hopkins
       University, Baltimore, MD, USA.
 SO    Am J Epidemiol. 1996 Feb 1;143(3):278-82. Unique Identifier : AIDSLINE
       MED/96148853
 AB    To determine whether initial CD4 cell counts after human
       immunodeficiency virus (HIV) seroconversion have decreased over calendar
       time among participants in the Italian Seroconversion Study, HIV
       seroconverters who between 1985 and 1992 had a documented negative
       serology followed by a positive serology within 12 months and a first
       CD4 cell measurement within 24 months of seroconversion (defined as
       midpoint of negative and positive HIV tests) were cross-tabulated by
       year of seroconversion. Linear regression methods were used to examine
       temporal trends in initial CD4 level after adjustment for age, lag time
       of seroconversion, lag time of CD4 cell measurement, risk group, and
       clinical center. Between 1985 and 1992, the overall median initial CD4
       cell level after seroconversion was 660 microliters with a median lag
       time of 212 days and 137 days for seroconversion and first CD4 cell
       measurement, respectively. In univariate and multivariate models, the
       CD4 cell count increases of 4.3 and 4.2 cells microliters/year,
       respectively, were not statistically significant. These data do not
       identify a trend of lower CD4 counts following HIV seroconversion in
       Italy and suggest indirectly that HIV has probably not become more
       virulent between 1985 and 1992.
 DE    Adolescence  Adult  Cohort Studies  CD4 Lymphocyte Count  CD4-Positive
       T-Lymphocytes/*IMMUNOLOGY  Female  Human  HIV Antibodies/ANALYSIS  HIV
       Infections/EPIDEMIOLOGY/*IMMUNOLOGY  HIV
       Seropositivity/EPIDEMIOLOGY/*IMMUNOLOGY  HIV-1/*IMMUNOLOGY
       Italy/EPIDEMIOLOGY  Linear Models  Male  Middle Age  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).