Document 0349
 DOCN  M9650349
 TI    Cytomegalovirus infection of the brain in AIDS: a clinicopathological
       study.
 DT    9605
 AU    Setinek U; Wondrusch E; Jellinger K; Steuer A; Drlicek M; Grisold W;
       Lintner F; Institute of Pathology and Bacteriology, Vienna, Austria.
 SO    Acta Neuropathol (Berl). 1995;90(5):511-5. Unique Identifier : AIDSLINE
       MED/96136529
 AB    Based on neuropathological findings, a retrospective case control study
       of 39 patients with acquired immune deficiency syndrome (AIDS) and
       confirmed cytomegalovirus (CMV) infection of the brain is presented.
       Since 1989, the incidence has increased progressively and, in 1994, CMV
       was the most frequent opportunistic central nervous system (CNS)
       infection. Of the patients with CMV infections of the brain 16 had one
       or more coexisting secondary opportunistic and/or tumorous lesions in
       the CNS. Cerebral involvement by CMV was more frequent in patients with
       multiple extracerebral organ infections, while 7 among the 39 reported
       cases showed isolated CMV infection of the brain. The evaluation of the
       clinical records of 21 patients revealed neuropsychiatric signs and
       symptoms in 10, while these were absent in 11. All of these patients
       revealed various types of cerebral lesions related to CMV infection:
       ventriculitis, focal lesions, and microglial nodule encephalitis. The
       extent and distribution of cerebral lesions showed no significant
       correlations with clinical, radiological, or laboratory findings.
       Further clinicopathological studies are warranted to recognize CMV
       infections of the CNS and to allow earlier and more efficient treatment
       of this rather frequent complication of AIDS.
 DE    Acquired Immunodeficiency Syndrome/MICROBIOLOGY/*PATHOLOGY  Adult
       Brain/MICROBIOLOGY/*PATHOLOGY  Cytomegalovirus
       Infections/MICROBIOLOGY/*PATHOLOGY  Female  Human  Male  Middle Age
       JOURNAL ARTICLE

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