Document 0352
 DOCN  M9650352
 TI    Computer simulations to predict the availability of peptides with known
       HLA class I motifs possibly generated by proteolysis of HIV-1 proteins
       in infected cells.
 DT    9605
 AU    Becker Y; Department of Molecular Virology, Faculty of Medicine, Hebrew;
       University of Jerusalem, Israel.
 SO    Virus Genes. 1995;10(3):227-37. Unique Identifier : AIDSLINE
       MED/96124518
 AB    Cytotoxic T cells that recognize HIV-1 peptides generated from all viral
       proteins were reported. To predict the cleavage pattern of HIV-1
       proteins by cytoplasmic proteasomes into peptides with motifs fitting
       known HLA class I molecules, the computer program Findpatterns was used.
       In this paper the combined amino acids patterns for proteolytic
       cleavages and the HLA class I haplotype-restricted peptides motifs are
       studied. It was noted that peptides with motifs of HLA class I A2 and
       A68 were abundant compared with HLA class 5B2, B8, B53, and B35.
 DE    Amino Acid Sequence  Amino Acids/METABOLISM  Antigen Presentation
       *Computer Simulation  Cysteine Proteinases/METABOLISM
       Histocompatibility Antigens Class I/*IMMUNOLOGY  Human  HIV
       Protease/METABOLISM  HIV-1/*IMMUNOLOGY  Molecular Sequence Data
       Multienzyme Complexes/METABOLISM  Peptide
       Fragments/IMMUNOLOGY/METABOLISM  Peptide Peptidohydrolases/METABOLISM
       Software  Support, Non-U.S. Gov't  T-Lymphocytes, Cytotoxic/*IMMUNOLOGY
       Viral Nonstructural Proteins/IMMUNOLOGY/METABOLISM  Viral
       Proteins/*IMMUNOLOGY/METABOLISM  Viral Structural
       Proteins/IMMUNOLOGY/METABOLISM  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).