Document 0373
 DOCN  M9650373
 TI    Reduction of HIV concentration during acute infection: independence from
       a specific immune response.
 DT    9605
 AU    Phillips AN; Department of Primary Care and Population Sciences, Royal
       Free; Hospital School of Medicine, London, UK.
 SO    Science. 1996 Jan 26;271(5248):497-9. Unique Identifier : AIDSLINE
       MED/96152367
 AB    After infection with the human immunodeficiency virus (HIV), the
       concentration of the virus in the person's plasma increases. The
       subsequent decrease in concentration a few weeks later was though to
       result from an HIV-specific immune response. This purported causal
       relation is investigated with a model of the dynamics of early HIV
       infection that incorporates no increase in the rate of removal of free
       virions or virus-infected cells. A pattern of changes in virus
       concentration similar to that observed in patients is predicted by the
       model. Thus, the reduction in virus concentration during acute infection
       may not reflect the ability of the HIV-specific immune response to
       control virus replication.
 DE    Acute Disease  CD4 Lymphocyte Count  CD4-Positive
       T-Lymphocytes/IMMUNOLOGY/*VIROLOGY  Human  HIV/*PHYSIOLOGY  HIV
       Infections/IMMUNOLOGY/*VIROLOGY  Lymphocyte Transformation  Mathematics
       *Models, Biological  Population Dynamics  Viremia/IMMUNOLOGY/*VIROLOGY
       Virion/PHYSIOLOGY  Virus Latency  Virus Replication  JOURNAL ARTICLE

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