Document 0376
 DOCN  M9650376
 TI    IFN-gamma restores HIV- and non-HIV-specific cell mediated immune
       response in vitro and its activity is neutralized by antibodies from
       patients with AIDS.
 DT    9605
 AU    De Francesco MA; Caruso A; Dima F; Cantalamessa A; Canaris AD; Folghera
       S; Fiorentini S; Flamminio G; Licenziati S; Peroni L; Gao J; Garotta G;
       Turano A; Insitute of Microbiology, University of Brescia, Italy.
 SO    Scand J Immunol. 1996 Jan;43(1):94-100. Unique Identifier : AIDSLINE
       MED/96151207
 AB    The addition of IFN-gamma to cultures of peripheral blood mononuclear
       cells (PBMCs) obtained from asymptomatic HIV-infected patients increased
       cell proliferation in response to HIV envelope synthetic peptides (Env),
       influenza A virus (VIRUS), and allogeneic lymphocytes (ALLO) but not to
       phytohaemagglutinin (PHA) stimulation. F(Ab)2 fragments of IgG purified
       from the sera of HIV-seropositive patients specifically interfered with
       IFN-gamma-induced cell proliferation in response to recall antigens.
       Neutralization of the lymphokine activity was found to be sustained by
       specific IFN-gamma antibodies. Data obtained demonstrate that IFN-gamma
       can restore the cell-mediated immunity of a number of asymptomatic HIV+
       individuals in vitro, while IFN-gamma antibodies present in sera of
       patients with AIDS interfere with the activity of the lymphokine.
 DE    Acquired Immunodeficiency Syndrome/*IMMUNOLOGY  Amino Acid Sequence
       Antibodies, Monoclonal/*IMMUNOLOGY  Human  HIV Antibodies/IMMUNOLOGY
       HIV Envelope Protein gp120/PHARMACOLOGY  HIV Infections/*IMMUNOLOGY  HIV
       Seronegativity/*IMMUNOLOGY  IgG/IMMUNOLOGY  Immunity, Cellular
       Immunoglobulins, Fab/IMMUNOLOGY  Interferon Type II/*IMMUNOLOGY
       Interferon-gamma, Recombinant/IMMUNOLOGY  Isoantigens/IMMUNOLOGY
       Lymphocyte Transformation/DRUG EFFECTS/IMMUNOLOGY  Molecular Sequence
       Data  Orthomyxovirus Type A, Human/IMMUNOLOGY  Peptide
       Fragments/PHARMACOLOGY  Support, Non-U.S. Gov't
       T-Lymphocytes/*IMMUNOLOGY  JOURNAL ARTICLE

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