Document 0382
 DOCN  M9650382
 TI    Probability and characteristics of human immunodeficiency virus
       infection in male Greek military personnel with tuberculosis.
 DT    9605
 AU    Bouros D; Panagou P; Tzanakis N; Siafakas N; Department of Thoracic
       Medicine, Medical School, University of; Crete, Heraklion, Greece.
 SO    Respiration. 1995;62(5):280-5. Unique Identifier : AIDSLINE MED/96079419
 AB    The probability of an AIDS patient being infected with tuberculosis (TB)
       has been studied in different populations and found to be increased by
       as much as 500 times, but the reverse, i.e. the probability of a patient
       with TB being infected with HIV, has not been studied. The aim of this
       study was to investigate the hypothesis of greater HIV seropositivity
       and altered immune status, as indicated by CD4+ T-lymphocyte counts, in
       TB patients. We prospectively studied 162 males, aged 18-30 years,
       hospitalized for active, proven TB. Serum for HIV antibodies was tested
       twice by ELISA and confirmed by the Western blot technique. The control
       group consisted of 145,000 blood donor volunteers serving in the army,
       aged 18-30 years. The number of CD4+ T lymphocytes was also measured in
       the patients and the control group. We found that the rate of HIV
       seropositivity in TB patients was 2.4% (4 of 162), while it was 0.214%
       in the control group (p < 0.0001). Using the Bayes' theorem we found
       that the probability of a TB patient being infected with HIV was 9.1%,
       approximately 150 times higher than the expected rate in the matched
       control group (p < 0.0001). The number of CD4+ T lymphocytes was
       significantly lower in pulmonary and extrapulmonary TB patients than in
       the control group, taking into account the HIV status (p < 0.001). Our
       results suggest that there is a 150 times greater probability of a TB
       patient being infected with HIV. CD4+ T lymphocytes are significantly
       lower in all groups of TB patients.
 DE    Adolescence  Adult  AIDS-Related Opportunistic
       Infections/*COMPLICATIONS/EPIDEMIOLOGY  Bayes Theorem  CD4 Lymphocyte
       Count  Greece/EPIDEMIOLOGY  Human  HIV
       Infections/*COMPLICATIONS/EPIDEMIOLOGY  HIV
       Seropositivity/*COMPLICATIONS/EPIDEMIOLOGY  Male  *Military Personnel
       Prevalence  Prospective Studies
       Tuberculosis/*COMPLICATIONS/EPIDEMIOLOGY  JOURNAL ARTICLE

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