Document 0404
 DOCN  M9650404
 TI    [Relationship between chronic liver diseases and hepatitis C in Burundi
       adults]
 DT    9605
 AU    Aubry P; Larouze B; Muhirwa G; Henzel D; Ndabaneze E; Nsabimana JM;
       Departement de Medecine Interne, Centre Hospitalier; Universitaire
       Kamenge, Bujumbura, Burundi.
 SO    Med Trop (Mars). 1995;55(3):235-7. Unique Identifier : AIDSLINE
       MED/96141169
 AB    A case/control study was conducted in Bujumbura, Burundi, from 1991 to
       1992 to assess the relationship between chronic liver disease and
       hepatitis C virus (HCV). Patients presenting chronic liver disease (n =
       80) were selected based on clinical, laboratory, ultrasonographic,
       and/or endoscopic findings. Patients with AIDS or hepatocellular
       carcinoma were excluded. Controls (n = 159) matched with regard to age
       and sex were recruited from outpatients who had blood tests at a liver
       disease clinic. Patients and controls were tested for anti-HCV
       antibodies by ELISA and LIA. Screening for hepatitis B virus (HBs
       antigen, anti-HBs and anti-HBc antibodies) and human immunodeficiency
       virus (HIV) was achieved by ELISA with confirmation of HIV infection by
       LIA. The incidence of anti-HCV antibodies was significantly higher in
       patients (55.0%) than controls (33.3%) (p < 0.001). The incidence of HBs
       antigens was significantly higher in patients (28.8%) than controls
       (7.5%) (p < 0.0001). The incidence of anti-HIV antibodies was not
       significantly different in the two groups. Multifactorial analysis
       indicated that anti-HCV antibodies and HBs antigens were risk factors
       for chronic liver disease, but did not detected a significant
       interaction between these two risk factors. Prevention of hepatitis C
       and B would reduce the incidence of chronic liver disease but cost
       currently limits widespread use of this approach.
 DE    Adolescence  Adult  Aged  Burundi  Case-Control Studies  Chronic Disease
       English Abstract  Female  Hepatitis C/*COMPLICATIONS/IMMUNOLOGY
       Hepatitis C Antibodies/BLOOD  Human  Incidence  Liver
       Diseases/IMMUNOLOGY/*VIROLOGY  Male  Middle Age  Multivariate Analysis
       Seroepidemiologic Methods  Urban Health  JOURNAL ARTICLE

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