Document 0420
 DOCN  M9650420
 TI    Necrotizing ulcerative gingivitis, periodontitis, and stomatitis:
       clinical staging and predisposing factors.
 DT    9605
 AU    Horning GM; Cohen ME; Naval Dental School, Bethesda, MD, USA.
 SO    J Periodontol. 1995 Nov;66(11):990-8. Unique Identifier : AIDSLINE
       MED/96162545
 AB    Necrotizing ulcerative gingivitis (NUG), necrotizing ulcerative
       periodontitis (NUP), and necrotizing stomatitis (NS), collectively
       termed necrotizing gingivostomatitis (NG), represent a dramatic, but
       rare oral infection associated with diminished systemic resistance,
       including HIV infection. Over a 5-year period, 68 consecutive NG
       patients from a population with known HIV status were evaluated and
       treated. Lesions were staged (modified Pindborg), and clinical findings
       and predictor variables were compared to 68 random control subjects
       without NG. Most cases (52%) were stage 1, with necrosis of the tip of
       the interdental papilla only; 19% were stage 2, with the entire papilla
       affected; 22% had necrosis of marginal (stage 3) or attached gingiva
       (stage 4); and 7% were more advanced, with mucosal necrosis or bone
       exposure. Attachment loss was a feature of stage 2 or greater NG. Beside
       HIV infection, significant predisposing factors included poor oral
       hygiene, unusual life stress, inadequate sleep, Caucasian race, age 18
       to 21 years, and recent illness. Ten of 68 NG patients were
       HIV-positive. These patients were older than seronegative patients, less
       likely to be Caucasian, and maintained better oral hygiene and sleep.
       HIV-positive NG cases were clinically indistinguishable from
       HIV-negative cases in this series.
 DE    Adult  Analysis of Variance  Bacterial
       Infections/EPIDEMIOLOGY/ETIOLOGY/IMMUNOLOGY/*PATHOLOGY  Bacteroidaceae
       California/EPIDEMIOLOGY  Case-Control Studies  Disease Susceptibility
       Ethnic Groups  Female  Fusobacterium  Gingivitis, Necrotizing
       Ulcerative/EPIDEMIOLOGY/ETIOLOGY/  IMMUNOLOGY/*PATHOLOGY  Human  HIV
       Seronegativity  HIV Seropositivity/COMPLICATIONS  Immunocompromised Host
       Male  Military Personnel  Multivariate Analysis  Odds Ratio  Oral
       Hygiene  Periodontal Attachment Loss/PATHOLOGY  Prevotella intermedia
       Recurrence  Risk Factors  Seasons  Sleep Deprivation  Stress,
       Psychological/COMPLICATIONS  Treponema  United States/EPIDEMIOLOGY
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).