Document 0429
 DOCN  M9650429
 TI    Adoptively transferred CD8+ T lymphocytes provide protection against
       TMEV-induced demyelinating disease in BALB/c mice.
 DT    9605
 AU    Nicholson SM; Dal Canto MC; Miller SD; Melvold RW; Department of
       Microbiology-Immunology, Northwestern University; Medical School,
       Chicago, IL 60611, USA.
 SO    J Immunol. 1996 Feb 1;156(3):1276-83. Unique Identifier : AIDSLINE
       MED/96144355
 AB    On intracerebral infection with the BeAn strain of Theiler's murine
       encephalomyelitis virus (TMEV), certain mouse strains develop a chronic
       demyelinating disease similar both clinically and pathologically to
       human multiple sclerosis. Other strains remain resistant. We previously
       established that differential susceptibility to this demyelinating
       disease exists among BALB/c substrains, with BALB/cAnNCr mice being
       susceptible while BALB/cByJ mice are resistant. BALB/cByJ mice are
       rendered susceptible to TMEV-induced demyelination on exposure to low
       dose gamma-irradiation before TMEV infection. BALB/cAnNCr and
       irradiated, infected BALB/cByJ animals are protected against
       TMEV-induced demyelination by the transfer of a splenic population from
       TMEV-infected BALB/cByJ donors. Resistance to demyelination appears to
       be mediated by a CD8+ radiosensitive population, which is induced on
       infection with TMEV and which must act early to establish resistance to
       TMEV-induced demyelination.
 DE    Animal  CD8-Positive T-Lymphocytes/RADIATION EFFECTS/*TRANSPLANTATION
       Demyelinating Diseases/IMMUNOLOGY/PREVENTION & CONTROL  Disease
       Susceptibility  Dose-Response Relationship, Radiation  Immune
       Tolerance/RADIATION EFFECTS  Immunity, Natural/RADIATION EFFECTS
       *Immunotherapy, Adoptive  Mice  Mice, Inbred BALB C
       Poliomyelitis/*IMMUNOLOGY/PATHOLOGY/*PREVENTION & CONTROL  Polioviruses,
       Murine/*IMMUNOLOGY  Spleen/TRANSPLANTATION  Support, U.S. Gov't, P.H.S.
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).