Document 0433
 DOCN  M9650433
 TI    Steps toward gene therapy: 1. The initial trials.
 DT    9605
 AU    Blaese RM; Clinical Gene Therapy Branch, National Center for Human
       Genome; Research, National Institutes of Health, Bethesda, Md., USA.
 SO    Hosp Pract (Off Ed). 1995 Nov 15;30(11):33-40. Unique Identifier :
       AIDSLINE MED/96110745
 AB    Hopes for correcting the instruction tape in patients with genetic
       disease are being intensively explored. Initial efforts centered on
       monogenic immunodeficiency states, but in a pattern not wholly expected
       by researchers, the acquired genetic diseases of cancer and AIDS account
       for most ongoing clinical trials. Experience with adenosine deaminase
       deficiency shows the difficulties encountered in creating practical gene
       therapies.
 DE    Adenosine Deaminase/*DEFICIENCY  Child, Preschool  Gene Therapy/*METHODS
       Genetic Engineering  Genetic Vectors  Human  Moloney Leukemia Virus
       Severe Combined Immunodeficiency/ENZYMOLOGY/GENETICS/*THERAPY  JOURNAL
       ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).