Document 0449
 DOCN  M9650449
 TI    Cerebrospinal fluid antiganglioside antibodies in patients with AIDS.
 DT    9605
 AU    Sorice M; Griggi T; Circella A; Nicodemo G; Ciardi M; Mastroianni CM;
       Lenti L; Sorice F; Dip. Malattie Infettive e Tropicali, Universita La
       Sapienza,; Rome, Italy.
 SO    Infection. 1995 Sep-Oct;23(5):288-91. Unique Identifier : AIDSLINE
       MED/96128589
 AB    In this study the presence of brain antiganglioside antibodies in the
       cerebrospinal fluid (CSF) of patients with HIV infection was analysed.
       CSF samples were collected from 45 patients with AIDS and from 45
       anti-HIV negative subjects, 15 of whom presented aseptic meningitis.
       Nineteen AIDS patients had clinically well-documented encephalopathy.
       Thirteen of these patients had white matter lesions shown by magnetic
       resonance imaging (MRI). Both IgG and IgM antiganglioside antibodies
       were detected by immunostaining on thin layer chromatography plates in
       three CSF samples from AIDS patients with progressive encephalopathy
       with signs of a diffuse demyelination, as revealed by MRI. Two of these
       CSF samples reacted specifically with GM3, GM1 and GD1a and one with
       GD1a. In none of the HIV infected patients without demyelinating
       encephalopathy, but with opportunistic infections or cerebral lymphoma,
       nor in the anti-HIV negative control subjects were antiganglioside
       antibodies detected. No association with JCV DNA, CMV DNA, EBV DNA,
       detected by nested PCR, nor HIV antigen p24 was found. These findings
       show the presence of brain antiganglioside antibodies in the CSF of AIDS
       patients for the first time. However, the findings do not suggest
       relating the presence of these antibodies to HIV encephalopathy or
       particular viral agents, but indicate that the antibodies are detectable
       in subjects with progressive encephalopathy with a diffuse
       demyelination.
 DE    Acquired Immunodeficiency Syndrome/CEREBROSPINAL FLUID/  *IMMUNOLOGY
       Adult  Animal  Antibodies/*CEREBROSPINAL FLUID  Antibodies,
       Antinuclear/CEREBROSPINAL FLUID  Female  Gangliosides/*IMMUNOLOGY  Human
       Magnetic Resonance Imaging  Male  Meningitis, Aseptic/CEREBROSPINAL
       FLUID/COMPLICATIONS  Tumor Cells, Cultured  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).