Document 0456
 DOCN  M9650456
 TI    Human papillomavirus is associated with the frequent detection of warty
       and basaloid high-grade neoplasia of the vulva and cervical neoplasia
       among immunocompromised women.
 DT    9605
 AU    Petry KU; Kochel H; Bode U; Schedel I; Niesert S; Glaubitz M; Maschek H;
       Kuhnle H; Department of Gynecological Oncology, University of Hannover,;
       Germany.
 SO    Gynecol Oncol. 1996 Jan;60(1):30-4. Unique Identifier : AIDSLINE
       MED/96139371
 AB    A total of 158 women who either HIV-infected or under iatrogenic
       immunosuppression were examined regularly during a 4-year period to
       evaluate if certain vulvar neoplasms and cervical neoplasia have similar
       associated risk factors. Patients with CIN were matched prospectively
       with immunocompetent controls with CIN. Forty-eight cervical lesions
       were detected among patients, including 2 invasive carcinoma and 15
       CIN-3 lesions, compared to 11 vulvar lesions, including 2 invasive
       carcinoma and 7 VIN-3 lesions. Women who have more than five life-time
       partners were more likely to have HPV-DNA positive cervical swabs and
       vulvar scrapes as well as cervical and/or vulvar neoplasia. Compared to
       2.7% of controls 15.2% of patients with CIN had coexisting high-grade
       lesions of the vulva. With 1 exception all patients with vulvar
       neoplasia either suffered from symptomatic immunodeficiency or received
       immunosuppressive drugs for more than 10 years. Except for 1 VIN-3
       lesions, all vulvar neoplasms were associated with HPV-DNA types 16, 31,
       and/or 33. Six of nine patients as well as the 2 controls with
       coexisting vulvar and cervical neoplasia had the same HPV-type
       associated with both lesions. All vulvar lesions were classified as
       either warty or basaloid. In conclusion cervical and bowenoid/basaloid
       vulvar neoplasia seem to have a similar HPV-related genesis. Malfunction
       of the cellular immune response appears to be a cofactor in the genesis
       of HPV-associated neoplasia at both sites.
 DE    Case-Control Studies  Cervical Intraepithelial Neoplasia/VIROLOGY
       Cervix Diseases/*VIROLOGY  Cervix Neoplasms/*VIROLOGY  Condylomata
       Acuminata/*VIROLOGY  DNA Probes, HPV  Female  Human  *Immunocompromised
       Host  Neoplasms, Basal Cell/*VIROLOGY  Papillomavirus,
       Human/GENETICS/*ISOLATION & PURIF  Prospective Studies  Vulvar
       Diseases/*VIROLOGY  Vulvar Neoplasms/*VIROLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).