Document 0462
 DOCN  M9650462
 TI    Peripheral gamma delta T-cell populations in HIV-infected individuals
       with mycobacterial infection.
 DT    9605
 AU    Ruiz P; Geraldino N; Department of Pathology, University of Miami School
       of Medicine,; Florida.
 SO    Cytometry. 1995 Sep 15;22(3):211-6. Unique Identifier : AIDSLINE
       MED/96106604
 AB    Previous studies have suggested that gamma delta T cells can be
       increased in HIV-1-seropositive individuals, although characterization
       of gamma delta T cell subtypes and correlation with clinical status of
       these patients have not been performed. We investigated groups of
       HIV-seropositive persons to determine the prevalence of elevated levels
       of gamma delta T cells and whether any gamma delta T cell subtypes were
       preferentially expressed. Since a large proportion of human gamma delta
       T cells appear to be reactive to proteins encoded by mycobacteria, we
       also examined our patients for the incidence of mycobacterial infection.
       Our results show that a significant number of HIV-positive patients have
       an elevated number of gamma delta T cells in their peripheral blood as
       compared to normal controls. HIV-seropositive patients with clinical or
       laboratory evidence of mycobacterial infection had statistically
       significant increases in the percentage and total numbers of gamma delta
       T cells over the HIV-positive persons without mycobacterial infection.
       An examination of the subtypes of gamma delta T cells revealed that
       certain subtypes such as V gamma 9+ and V delta 2+ T cells were
       preferentially elevated in the mycobacteria-positive patients. These
       results suggest that an increased number of gamma delta T cells in
       HIV-positive patients is most often seen in the setting of an
       opportunistic mycobacterial infection and that specific gamma delta T
       cell subtypes are stimulated under these conditions. The role of these
       increased number of gamma delta T cells in HIV-associated disease is
       unclear but is likely a component of the response and degree of host
       resistance to this organism.
 DE    Adult  AIDS-Related Opportunistic Infections/COMPLICATIONS/*IMMUNOLOGY
       Female  Flow Cytometry  Human  HIV
       Seropositivity/COMPLICATIONS/*IMMUNOLOGY  Male  Mycobacterium
       Infections/COMPLICATIONS/*IMMUNOLOGY/MICROBIOLOGY  Receptors, Antigen,
       T-Cell, gamma-delta/*IMMUNOLOGY  T-Lymphocyte Subsets/*IMMUNOLOGY
       JOURNAL ARTICLE

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