Document 0475
 DOCN  M9650475
 TI    Antineurofilament and antiretinal antibodies in AIDS patients with
       cytomegalovirus retinitis.
 DT    9605
 AU    Rosberger DF; Tshering SL; Polsky B; Heinemann MH; Klein RF;
       Cunningham-Rundles S; Department of Ophthalmology, Cornell University
       Medical College,; New York, New York 10021, USA.
 SO    Clin Diagn Lab Immunol. 1994 Jul;1(4):445-9. Unique Identifier :
       AIDSLINE MED/96050853
 AB    Sera obtained from AIDS patients with cytomegalovirus (CMV) retinitis
       before and after treatment with foscarnet, AIDS patients with human
       immunodeficiency virus (HIV) retinopathy, AIDS patients without retinal
       disease, and normal healthy controls with and without positive CMV
       serologies were assayed for the presence of antibodies against the
       200-kDa outer, 160-kDa middle, and 68-kDa core subunits of the
       neurofilament triplet. Additional studies were performed to determine
       the presence of antibodies reactive with proteins extracted from crude
       human retinal antigen preparations. Antibodies against the 200-, 260-,
       and 68-kDa proteins of the neurofilament triplet were detected in 15 of
       15 AIDS patients with CMV retinitis. The expression of these antibodies
       was unaffected, qualitatively, by successful treatment with foscarnet.
       In contrast, only 30% of patients with HIV retinopathy unrelated to CMV,
       fewer than 35% of AIDS patients with positive CMV titers but without
       evident retinitis, and fewer than 25% of healthy controls with positive
       or negative CMV titers possessed antibodies against any of the triplet
       proteins (P < 0.001). Antibodies against several clusters of retinal
       antigens were also identified in the sera of patients with CMV
       retinitis. In summary, the data indicate that retinal elements damaged
       by CMV infection induce an antibody response against the 200-, 160-, and
       68kDa components of the neurofilament triplet as well as other, as yet
       undefined retinal antigens.
 DE    Acquired Immunodeficiency Syndrome/COMPLICATIONS/*IMMUNOLOGY
       Antibodies/*BLOOD  Antiviral Agents/ADMINISTRATION & DOSAGE  Comparative
       Study  Cytomegalovirus Retinitis/DIAGNOSIS/*IMMUNOLOGY
       Foscarnet/ADMINISTRATION & DOSAGE  Human  Male  Necrosis  Neurofilament
       Proteins/*IMMUNOLOGY  Retina/*IMMUNOLOGY/PATHOLOGY  Support, Non-U.S.
       Gov't  Support, U.S. Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).