Document 0486
 DOCN  M9650486
 TI    Marital status in relation to Kaposi's sarcoma, non-Hodgkin's lymphoma,
       and anal cancer in the pre-AIDS era.
 DT    9605
 AU    Biggar RJ; Melbye M; Viral Epidemiology Branch, National Cancer
       Institute, Bethesda,; Maryland, USA.
 SO    J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Feb 1;11(2):178-82.
       Unique Identifier : AIDSLINE MED/96147318
 AB    Persons with human immunodeficiency virus/AIDS are at high risk of
       Kaposi's sarcoma (KS), non-Hodgkin lymphoma (NHL), and possibly anal
       cancers. To examine whether this risk preceded the AIDS epidemic, we
       used pre-AIDS era data from the Surveillance, Epidemiology, and End
       Results program (excluding Connecticut) from 1973 to 1976, and the
       Connecticut Tumor Registry from 1940 to 1976. We compared risk of being
       single (a surrogate to identify men who might be homosexual) to those
       ever married, using a case control matching study with up to 10 controls
       per case. Overall, no excess risk was observed for KS (risk ratio for
       men 20-59 years old: 1.00; 95% confidence interval 0.218-3.61), but
       there was a suggestion of higher risk (4.00; 0.54-29.48) in 1973-1976,
       the period just before the AIDS epidemic. The NHL risk (0.85; 0.74-0.99)
       was slightly low, but for anal cancer the risk ratio of being single was
       significantly high both in men 20-59 years old (5.68) and older men
       (2.78) long before the AIDS epidemic. If the excess risk was solely due
       to being homosexual, the actual relative risk in the subset who were
       homosexual must have been much higher, given that only a fraction of the
       single men would have been homosexual. As comparison groups to verify
       the methodology, we used colon (no association with marital status) and
       prostatic cancer (decreased in single men), with findings as reported in
       other studies. Thus, single men may have been at an excess risk of KS
       (but a slightly low risk of NHL) just before the AIDS epidemic and have
       been at excess risk of anal cancer for many years before the AIDS
       epidemic.
 DE    Acquired Immunodeficiency Syndrome/*EPIDEMIOLOGY  Adult  Anus
       Neoplasms/*EPIDEMIOLOGY  Case-Control Studies  Colonic
       Neoplasms/EPIDEMIOLOGY  Comparative Study  Connecticut/EPIDEMIOLOGY
       Human  Lymphoma, Non-Hodgkin's/*EPIDEMIOLOGY  Male  *Marital Status
       Middle Age  Prostatic Neoplasms/EPIDEMIOLOGY  Registries  Risk Factors
       Sarcoma, Kaposi's/*EPIDEMIOLOGY  *SEER Program  United
       States/EPIDEMIOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).