Document 0497 DOCN M9650497 TI MHC class I-selected CD4-CD8-TCR alpha beta+ T cells: an important source of IL-4. DT 9605 AU Leite-de-Moraes MC; Dy M; Universite Rene Descartes, Paris, France. SO Braz J Med Biol Res. 1995 Aug;28(8):903-5. Unique Identifier : AIDSLINE MED/96098120 AB Differentiation of naive CD4+ lymphocytes into either Th1 or Th2 cells is influenced by the cytokine present during initial antigen priming. IL-4 is the critical element in the induction of Th2 response; however, its origin during a primary immune response is not well-defined. Here, a novel source of IL-4, the class I-selected CD4-CD8-TCR alpha beta+ T cells, potentially implicated in the development of specific Th2 immune cells, is reviewed. DE Animal Cell Differentiation CD4-Positive T-Lymphocytes/*PHYSIOLOGY CD8-Positive T-Lymphocytes/*PHYSIOLOGY Genes, MHC Class I/*PHYSIOLOGY Interleukin-4/*PHYSIOLOGY Mice Receptors, Antigen, T-Cell, alpha-beta/*PHYSIOLOGY JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL SOURCE: National Library of Medicine. NOTICE: This material may be protected by Copyright Law (Title 17, U.S.Code).