Document 0505
 DOCN  M9650505
 TI    [Intra-family transmission of human T-cell lymphotropic virus-1 (HTLV-1)
       in a cohort of HTLV-1-positive patients (Benin)]
 DT    9605
 AU    Houinato D; Verdier M; Josse R; Foundohou J; Preux PM; Avode G; Zohoun
       T; Denis F; Dumas M; Institut d'Epidemiologie neurologique et de
       neurologie; tropicale, Limoges.
 SO    Bull Soc Pathol Exot. 1995;88(3):79-80. Unique Identifier : AIDSLINE
       MED/96150674
 AB    We are reporting the results of a familial study carried out in Benin in
       March 1994 within a cohort of HTLV-1 positive subjects. This study aims
       at appraising the different modes of intra-familial transmission of this
       retrovirus. The study has included 212 persons: 33 seropositive subjects
       (identified during two previous seroprevalence surveys and followed up
       since 1991), and 179 members of their families. Blood specimens have
       been taken from each of these subjects. Sera have been screened for
       HTLV-1 antibodies by ELISA test and positive results confirmed by
       Western blot test. Out of 18 children born during the follow up period,
       2 cases of seroconversion have been observed. One case of seroconversion
       has also been noted among the 17 couples in which either of the spouses
       is seropositive. Among the 136 children of the cohort: 17.8% of them are
       HTLV-1 positive when both parents are seropositive 26.1% if the mother
       only is seropositive and 0% if the father only is seropositive. The
       incidence rate in this cohort is estimated to be 0.43%. These data
       relative to the intra-familial transmission of HTLV-1 in Benin appear to
       be consistent with those previously reported in Japan.
 DE    Benin  Blotting, Western  Child  Cohort Studies  *Disease Transmission,
       Vertical  English Abstract  Enzyme-Linked Immunosorbent Assay  Fathers
       Female  Follow-Up Studies  Human  HTLV-I/ISOLATION & PURIF  HTLV-I
       Antibodies/BLOOD  HTLV-I Infections/GENETICS/*TRANSMISSION  Incidence
       Male  Mothers  Seroepidemiologic Methods  JOURNAL ARTICLE

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