Document 0509
 DOCN  M9650509
 TI    Clinical neurophysiological comparative study on HTLV-1 associated
       myelopathy/tropical spastic paraparesis.
 DT    9605
 AU    Leon FE; Arimura K; Arimura Y; Sonoda Y; Suwazono S; Osame M; Third
       Department of Internal Medicine, Kagoshima University; School of
       Medicine, Japan.
 SO    Arch Med Res. 1995 Winter;26(4):397-403. Unique Identifier : AIDSLINE
       MED/96107859
 AB    In order to determine the neurophysiological characteristics of
       HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP)
       throughout the world, we analyzed and compared the most common clinical
       neurophysiological studies (CNPS) performed in this entity from those
       places with a high prevalence and interesting regional differences were
       noted. African patients showed a noteworthy involvement of the
       peripheral nervous system (PNS). Chilean patients displayed a more
       circumscribed abnormality around the spinal cord. The migrants from the
       West Indies to England showed important visual, and somatosensory evoked
       potential (SSEP) alterations in the upper limbs (UL). Japanese patients
       also presented some involvement of the PNS, but their illness duration
       was less protracted than that observed in other countries. The
       differences found in visual pathways and PNS involvement among these
       groups were statistically significant (p < 0.05). Thus, this study shows
       not only a widespread subclinical involvement in both central and PNS in
       HAM/TSP, but also strongly supports the idea that the lesion
       distribution and progression of this disease are different among
       countries. Such differences could likely be due to the action of the
       so-called environmental co-factors present in each of these areas which
       should be promptly investigated.
 DE    Comparative Study  Human  *HTLV-I  Nervous System/*PHYSIOPATHOLOGY
       Paraparesis, Tropical Spastic/*PHYSIOPATHOLOGY/*VIROLOGY  Support,
       Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).