Document 0510
 DOCN  M9650510
 TI    Ovine lentivirus infection: an animal model for pediatric HIV infection?
 DT    9605
 AU    de la Concha-Bermejillo A; Juste RA; Kretschmer R; Aguilar Setien A;
       Department of Pathology, Texas A & M University Agricultural; Experiment
       Station, San Angelo, USA.
 SO    Arch Med Res. 1995 Winter;26(4):345-54. Unique Identifier : AIDSLINE
       MED/96107853
 AB    While the incidence of the human immunodeficiency virus (HIV) infection
       has leveled off somewhat in homosexual men, infection in women, children
       and adolescents is rising. Unless effective preventive measures are
       introduced, the number of pediatric patients with HIV and related
       illnesses will continue to increase. Animal models play a key role in
       the understanding of the pathogenesis and in the establishment of
       therapeutic approaches of infectious diseases. Ovine lentivirus (OvLV)
       comprises a subgenus of the lentivirus genus in the family Retroviridae,
       that shares genotypic, phenotypic and pathogenic features with HIV.
       Infection of sheep with OvLV results in a progressive chronic disease
       characterized by cachexia and chronic active inflammation in the lungs,
       lymph nodes, joints, mammary gland and the central nervous system.
       Pulmonary lesions in OvLV-affected sheep consist of lymphoid
       interstitial pneumonia (LIP) and lyphocytic alveolitis. Similarly, these
       pulmonary lesions also occur in up to 40% of HIV-infected children and
       in some adults with AIDS. Neonatal lambs experimentally inoculated
       intratracheally with OvLV develop LIP in 5 to 6 months, thus shortening
       by several years the natural incubation period and resembling the
       shorter incubation period observed in children with HIV-associated LIP.
       However, unlike HIV, OvLV does not infect CD4+T lymphocytes; OvLV only
       infects and replicates in macrophages. Recent studies indicate that
       macrophage tropic HIV plays an important role in disease progression.
       Similarities between HIV and OvLV argue for the use of ovine lentivirus
       infection as a model to advance in the understanding of some of the
       aspects of HIV infection.(ABSTRACT TRUNCATED AT 250 WORDS)
 DE    Adult  Animal  Child  *Disease Models, Animal  Female  Human
       HIV/GENETICS  *HIV Infections/IMMUNOLOGY/MICROBIOLOGY  *Lentivirus
       Infections/IMMUNOLOGY/MICROBIOLOGY  Lentiviruses, Ovine-Caprine/GENETICS
       Male  Sheep  Support, Non-U.S. Gov't  Support, U.S. Gov't, Non-P.H.S.
       JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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